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4bmy

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==Structure of futalosine hydrolase mutant of Helicobacter pylori strain 26695==
==Structure of futalosine hydrolase mutant of Helicobacter pylori strain 26695==
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<StructureSection load='4bmy' size='340' side='right' caption='[[4bmy]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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<StructureSection load='4bmy' size='340' side='right'caption='[[4bmy]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bmy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Campylobacter_pylori Campylobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BMY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bmy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_26695 Helicobacter pylori 26695]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BMY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bmx|4bmx]], [[4bmz|4bmz]], [[4bn0|4bn0]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylhomocysteine_nucleosidase Adenosylhomocysteine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.9 3.2.2.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bmy OCA], [https://pdbe.org/4bmy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bmy RCSB], [https://www.ebi.ac.uk/pdbsum/4bmy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bmy ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bmy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bmy RCSB], [http://www.ebi.ac.uk/pdbsum/4bmy PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MTNN_HELPY MTNN_HELPY]] Responsible for cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH) (By similarity).
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[https://www.uniprot.org/uniprot/MQMTN_HELPY MQMTN_HELPY] Catalyzes the direct conversion of aminodeoxyfutalosine (AFL) into dehypoxanthine futalosine (DHFL) and adenine via the hydrolysis of the N-glycosidic bond; this reaction seems to represent an essential step in the menaquinone biosynthesis pathway in Helicobacter species. Can also probably catalyzes the hydrolysis of 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. These other activities highlight the tremendous versatility of the enzyme, which also plays key roles in S-adenosylmethionine recycling and in the biosynthesis of the quorum-sensing molecule autoinducer-2. Does not act on futalosine (FL) as substrate.<ref>PMID:21098241</ref> <ref>PMID:24083939</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4bmy" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Adenosylhomocysteine nucleosidase]]
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[[Category: Helicobacter pylori 26695]]
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[[Category: Campylobacter pylori]]
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[[Category: Large Structures]]
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[[Category: Davies, G J]]
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[[Category: Davies GJ]]
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[[Category: Kim, R Q]]
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[[Category: Kim RQ]]
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[[Category: Offen, W A]]
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[[Category: Offen WA]]
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[[Category: Stubbs, K A]]
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[[Category: Stubbs KA]]
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[[Category: Hydrolase]]
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Current revision

Structure of futalosine hydrolase mutant of Helicobacter pylori strain 26695

PDB ID 4bmy

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