4bqm
From Proteopedia
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(New page: '''Unreleased structure''' The entry 4bqm is ON HOLD Authors: Ferreira, I.M., Vollmar, M., Krojer, T., Strain-Damerell, C., Froese, S., Coutandin, D., Williams, E., Burgess-Brown, N., v...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human liver-type glutaminase, catalytic domain== | |
| + | <StructureSection load='4bqm' size='340' side='right'caption='[[4bqm]], [[Resolution|resolution]] 2.18Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4bqm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BQM FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqm OCA], [https://pdbe.org/4bqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bqm RCSB], [https://www.ebi.ac.uk/pdbsum/4bqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bqm ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GLSL_HUMAN GLSL_HUMAN] Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.<ref>PMID:20378837</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Glutaminase 3D structures|Glutaminase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ambrosio ALB]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Burgess-Brown N]] | ||
| + | [[Category: Coutandin D]] | ||
| + | [[Category: Dias SMG]] | ||
| + | [[Category: Edwards A]] | ||
| + | [[Category: Ferreira IM]] | ||
| + | [[Category: Froese S]] | ||
| + | [[Category: Krojer T]] | ||
| + | [[Category: Strain-Damerell C]] | ||
| + | [[Category: Vollmar M]] | ||
| + | [[Category: Williams E]] | ||
| + | [[Category: Yue WW]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Crystal structure of human liver-type glutaminase, catalytic domain
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Categories: Homo sapiens | Large Structures | Ambrosio ALB | Arrowsmith CH | Bountra C | Burgess-Brown N | Coutandin D | Dias SMG | Edwards A | Ferreira IM | Froese S | Krojer T | Strain-Damerell C | Vollmar M | Williams E | Yue WW | Von Delft F
