1p7c

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[[Image:1p7c.jpg|left|200px]]
[[Image:1p7c.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1p7c |SIZE=350|CAPTION= <scene name='initialview01'>1p7c</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1p7c", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=T5A:P1-(5&#39;-ADENOSYL)P5-(5&#39;-THYMIDYL)PENTAPHOSPHATE'>T5A</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= TK OR UL23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10298 Human herpesvirus 1])
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-->
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|DOMAIN=
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{{STRUCTURE_1p7c| PDB=1p7c | SCENE= }}
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|RELATEDENTRY=[[1p75|1P75]], [[1p72|1P72]], [[1p6x|1P6X]], [[1p73|1P73]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7c OCA], [http://www.ebi.ac.uk/pdbsum/1p7c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p7c RCSB]</span>
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}}
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'''Crystal Structure of HSV1-TK complexed with TP5A'''
'''Crystal Structure of HSV1-TK complexed with TP5A'''
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[[Category: Monnerjahn, C.]]
[[Category: Monnerjahn, C.]]
[[Category: Shuvalova, L.]]
[[Category: Shuvalova, L.]]
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[[Category: bisubstrate inhibitor]]
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[[Category: Bisubstrate inhibitor]]
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[[Category: lid]]
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[[Category: Lid]]
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[[Category: p-loop]]
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[[Category: P-loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:46:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:55:56 2008''
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Revision as of 01:46, 3 May 2008

Image:1p7c.jpg

Template:STRUCTURE 1p7c

Crystal Structure of HSV1-TK complexed with TP5A


Overview

Crystal structures of equine herpesvirus type-4 thymidine kinase (EHV4-TK) in complex with (i). thymidine and ADP, (ii). thymidine and SO(4) and the bisubstrate analogs, (iii). TP(4)A, and (iv). TP(5)A have been solved. Additionally, the structure of herpes simplex virus type-1 thymidine kinase (HSV1-TK) in complex with TP(5)A has been determined. These are the first structures of nucleoside kinases revealing conformational transitions upon binding of bisubstrate analogs. The structural basis for the dual thymidine and thymidylate kinase activity of these TKs is elucidated. While the active sites of HSV1-TK and EHV4-TK resemble one another, notable differences are observed in the Lid regions and in the way the enzymes bind the base of the phosphoryl-acceptor. The latter difference could partly explain the higher activity of EHV4-TK toward the prodrug ganciclovir.

About this Structure

1P7C is a Single protein structure of sequence from Human herpesvirus 1. Full crystallographic information is available from OCA.

Reference

Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases., Gardberg A, Shuvalova L, Monnerjahn C, Konrad M, Lavie A, Structure. 2003 Oct;11(10):1265-77. PMID:14527394 Page seeded by OCA on Sat May 3 04:46:34 2008

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