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4bvc
From Proteopedia
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==Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.== | ==Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.== | ||
| - | <StructureSection load='4bvc' size='340' side='right' caption='[[4bvc]], [[Resolution|resolution]] 1.60Å' scene=''> | + | <StructureSection load='4bvc' size='340' side='right'caption='[[4bvc]], [[Resolution|resolution]] 1.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4bvc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BVC OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4bvc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BVC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BVC FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BV5:3-(4-PIPERIDYL)-N-[2-(TRIFLUOROMETHOXY)PHENYL]SULFONYL-PROPANAMIDE'>BV5</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BV5:3-(4-PIPERIDYL)-N-[2-(TRIFLUOROMETHOXY)PHENYL]SULFONYL-PROPANAMIDE'>BV5</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bvc OCA], [https://pdbe.org/4bvc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bvc RCSB], [https://www.ebi.ac.uk/pdbsum/4bvc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bvc ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/APOA_HUMAN APOA_HUMAN] Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.<ref>PMID:2531657</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Althage | + | [[Category: Homo sapiens]] |
| - | [[Category: Andersson | + | [[Category: Large Structures]] |
| - | [[Category: Antonsson | + | [[Category: Althage M]] |
| - | [[Category: Blaho | + | [[Category: Andersson GMK]] |
| - | [[Category: Bodin | + | [[Category: Antonsson T]] |
| - | [[Category: Bostrom | + | [[Category: Blaho S]] |
| - | [[Category: Chen | + | [[Category: Bodin C]] |
| - | [[Category: Dahlen | + | [[Category: Bostrom J]] |
| - | [[Category: Eriksson | + | [[Category: Chen Y]] |
| - | [[Category: Evertsson | + | [[Category: Dahlen A]] |
| - | [[Category: Fex | + | [[Category: Eriksson PO]] |
| - | [[Category: Fjellstrom | + | [[Category: Evertsson E]] |
| - | [[Category: Gustafsson | + | [[Category: Fex T]] |
| - | [[Category: Hallberg | + | [[Category: Fjellstrom O]] |
| - | [[Category: Hicks | + | [[Category: Gustafsson D]] |
| - | [[Category: Jarkvist | + | [[Category: Hallberg C]] |
| - | [[Category: Johansson | + | [[Category: Hicks R]] |
| - | [[Category: Kalies | + | [[Category: Jarkvist E]] |
| - | [[Category: Kang | + | [[Category: Johansson C]] |
| - | + | [[Category: Kalies I]] | |
| - | [[Category: Kartberg | + | [[Category: Kang D]] |
| - | [[Category: Knecht | + | [[Category: Kartberg F]] |
| - | [[Category: Legnehed | + | [[Category: Knecht W]] |
| - | [[Category: Lindqvist | + | [[Category: Legnehed A]] |
| - | [[Category: Martinsson | + | [[Category: Lindqvist AM]] |
| - | [[Category: Moberg | + | [[Category: Martinsson SA]] |
| - | [[Category: Petersson | + | [[Category: Moberg A]] |
| - | [[Category: Ridderstrom | + | [[Category: Petersson AU]] |
| - | [[Category: Sandmark | + | [[Category: Ridderstrom M]] |
| - | [[Category: Thelin | + | [[Category: Sandmark J]] |
| - | [[Category: Tigerstrom | + | [[Category: Svalstedt Karlsson B]] |
| - | [[Category: Vinblad | + | [[Category: Thelin A]] |
| - | [[Category: Xu | + | [[Category: Tigerstrom A]] |
| - | + | [[Category: Vinblad J]] | |
| - | + | [[Category: Xu B]] | |
| - | + | ||
| - | + | ||
Current revision
Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.
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Categories: Homo sapiens | Large Structures | Althage M | Andersson GMK | Antonsson T | Blaho S | Bodin C | Bostrom J | Chen Y | Dahlen A | Eriksson PO | Evertsson E | Fex T | Fjellstrom O | Gustafsson D | Hallberg C | Hicks R | Jarkvist E | Johansson C | Kalies I | Kang D | Kartberg F | Knecht W | Legnehed A | Lindqvist AM | Martinsson SA | Moberg A | Petersson AU | Ridderstrom M | Sandmark J | Svalstedt Karlsson B | Thelin A | Tigerstrom A | Vinblad J | Xu B
