This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4bws

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:59, 20 December 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal structure of the heterotrimer of PQBP1, U5-15kD and U5-52kD.==
==Crystal structure of the heterotrimer of PQBP1, U5-15kD and U5-52kD.==
-
<StructureSection load='4bws' size='340' side='right' caption='[[4bws]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+
<StructureSection load='4bws' size='340' side='right'caption='[[4bws]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4bws]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BWS FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4bws]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BWS FirstGlance]. <br>
-
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bwq|4bwq]]</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bws OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bws RCSB], [http://www.ebi.ac.uk/pdbsum/4bws PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bws OCA], [https://pdbe.org/4bws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bws RCSB], [https://www.ebi.ac.uk/pdbsum/4bws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bws ProSAT]</span></td></tr>
</table>
</table>
-
== Disease ==
 
-
[[http://www.uniprot.org/uniprot/PQBP1_HUMAN PQBP1_HUMAN]] X-linked intellectual deficit, Sutherland-Haan type;X-linked intellectual deficit, Golabi-Ito-Hall type;X-linked intellectual deficit, Porteous type;Hamel cerebro-palato-cardiac syndrome. The disease is caused by mutations affecting the gene represented in this entry.
 
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/TXN4A_HUMAN TXN4A_HUMAN]] Essential role in pre-mRNA splicing. [[http://www.uniprot.org/uniprot/PQBP1_HUMAN PQBP1_HUMAN]] May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit.<ref>PMID:10332029</ref> <ref>PMID:10198427</ref> <ref>PMID:12062018</ref>
+
[https://www.uniprot.org/uniprot/TXN4A_HUMAN TXN4A_HUMAN] Essential role in pre-mRNA splicing.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 18: Line 17:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4bws" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[U5-15kD|U5-15kD]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Kojima, R]]
+
[[Category: Large Structures]]
-
[[Category: Mizuguchi, M]]
+
[[Category: Kojima R]]
-
[[Category: Morimoto, T]]
+
[[Category: Mizuguchi M]]
-
[[Category: Nabeshima, Y]]
+
[[Category: Morimoto T]]
-
[[Category: Obita, T]]
+
[[Category: Nabeshima Y]]
-
[[Category: Okazawa, H]]
+
[[Category: Obita T]]
-
[[Category: Serita, T]]
+
[[Category: Okazawa H]]
-
[[Category: Neurodegenerative disorder]]
+
[[Category: Serita T]]
-
[[Category: Transcription]]
+

Current revision

Crystal structure of the heterotrimer of PQBP1, U5-15kD and U5-52kD.

PDB ID 4bws

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4bws"
Personal tools