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4c0a

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==Arf1(Delta1-17)in complex with BRAG2 Sec7-PH domain==
==Arf1(Delta1-17)in complex with BRAG2 Sec7-PH domain==
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<StructureSection load='4c0a' size='340' side='right' caption='[[4c0a]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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<StructureSection load='4c0a' size='340' side='right'caption='[[4c0a]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4c0a]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C0A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4c0a]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C0A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G3D:GUANOSINE-3-MONOPHOSPHATE-5-DIPHOSPHATE'>G3D</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c0a RCSB], [http://www.ebi.ac.uk/pdbsum/4c0a PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G3D:GUANOSINE-3-MONOPHOSPHATE-5-DIPHOSPHATE'>G3D</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0a OCA], [https://pdbe.org/4c0a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c0a RCSB], [https://www.ebi.ac.uk/pdbsum/4c0a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c0a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ARF1_BOVIN ARF1_BOVIN]] GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles.
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[https://www.uniprot.org/uniprot/IQEC1_HUMAN IQEC1_HUMAN] In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin.<ref>PMID:11226253</ref> <ref>PMID:16461286</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4c0a" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Aizel, K]]
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[[Category: Large Structures]]
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[[Category: Biou, V]]
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[[Category: Aizel K]]
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[[Category: Campanacci, V]]
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[[Category: Biou V]]
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[[Category: Cherfils, J]]
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[[Category: Campanacci V]]
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[[Category: Duarte, L]]
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[[Category: Cherfils J]]
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[[Category: Navaza, J]]
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[[Category: Duarte L]]
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[[Category: Zeghouf, M]]
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[[Category: Navaza J]]
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[[Category: Endocytosis]]
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[[Category: Zeghouf M]]
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[[Category: Protein transport]]
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Current revision

Arf1(Delta1-17)in complex with BRAG2 Sec7-PH domain

PDB ID 4c0a

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