This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4cc5
From Proteopedia
(Difference between revisions)
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
==Fragment-Based Discovery of 6 Azaindazoles As Inhibitors of Bacterial DNA Ligase== | ==Fragment-Based Discovery of 6 Azaindazoles As Inhibitors of Bacterial DNA Ligase== | ||
| - | <StructureSection load='4cc5' size='340' side='right' caption='[[4cc5]], [[Resolution|resolution]] 1.88Å' scene=''> | + | <StructureSection load='4cc5' size='340' side='right'caption='[[4cc5]], [[Resolution|resolution]] 1.88Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4cc5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CC5 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4cc5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CC5 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L5V:2-CHLORANYL-6-(1H-1,2,4-TRIAZOL-3-YL)PYRAZINE'>L5V</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cc5 OCA], [https://pdbe.org/4cc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cc5 RCSB], [https://www.ebi.ac.uk/pdbsum/4cc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cc5 ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DNLJ_STAAU DNLJ_STAAU] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 18: | Line 19: | ||
</div> | </div> | ||
<div class="pdbe-citations 4cc5" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4cc5" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[DNA ligase 3D structures|DNA ligase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Amin | + | [[Category: Large Structures]] |
| - | [[Category: Benowitz | + | [[Category: Staphylococcus aureus]] |
| - | [[Category: Chiarparin | + | [[Category: Amin N]] |
| - | [[Category: Cui | + | [[Category: Benowitz AB]] |
| - | [[Category: Deng | + | [[Category: Chiarparin E]] |
| - | [[Category: Heightman | + | [[Category: Cui H]] |
| - | [[Category: Holmes | + | [[Category: Deng X]] |
| - | [[Category: Hopkins | + | [[Category: Heightman TD]] |
| - | [[Category: Howard | + | [[Category: Holmes DJ]] |
| - | [[Category: Huang | + | [[Category: Hopkins A]] |
| - | [[Category: Jin | + | [[Category: Howard S]] |
| - | [[Category: Kreatsoulas | + | [[Category: Huang J]] |
| - | [[Category: Martin | + | [[Category: Jin Q]] |
| - | [[Category: Massey | + | [[Category: Kreatsoulas C]] |
| - | [[Category: McCloskey | + | [[Category: Martin ACL]] |
| - | [[Category: Mortenson | + | [[Category: Massey F]] |
| - | [[Category: Pathuri | + | [[Category: McCloskey L]] |
| - | [[Category: Tisi | + | [[Category: Mortenson PN]] |
| - | [[Category: Williams | + | [[Category: Pathuri P]] |
| - | + | [[Category: Tisi D]] | |
| - | + | [[Category: Williams PA]] | |
Current revision
Fragment-Based Discovery of 6 Azaindazoles As Inhibitors of Bacterial DNA Ligase
| |||||||||||
Categories: Large Structures | Staphylococcus aureus | Amin N | Benowitz AB | Chiarparin E | Cui H | Deng X | Heightman TD | Holmes DJ | Hopkins A | Howard S | Huang J | Jin Q | Kreatsoulas C | Martin ACL | Massey F | McCloskey L | Mortenson PN | Pathuri P | Tisi D | Williams PA
