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4cis

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<StructureSection load='4cis' size='340' side='right'caption='[[4cis]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
<StructureSection load='4cis' size='340' side='right'caption='[[4cis]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4cis]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"streptococcus_hollandicus"_scholl_1891 "streptococcus hollandicus" scholl 1891]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CIS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CIS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4cis]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_cremoris Lactococcus cremoris] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CIS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=68Z:1R,2S,4R)-4-[2-AZANYL-6,8-BIS(OXIDANYLIDENE)-1,7-DIHYDROPURIN-9-YL]-2-OXIDANYL-CYCLOPENTYL]METHYL+DIHYDROGEN+PHOSPHATE'>68Z</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=68Z:1R,2S,4R)-4-[2-AZANYL-6,8-BIS(OXIDANYLIDENE)-1,7-DIHYDROPURIN-9-YL]-2-OXIDANYL-CYCLOPENTYL]METHYL+DIHYDROGEN+PHOSPHATE'>68Z</scene>, <scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-formamidopyrimidine_glycosylase DNA-formamidopyrimidine glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.23 3.2.2.23] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cis OCA], [https://pdbe.org/4cis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cis RCSB], [https://www.ebi.ac.uk/pdbsum/4cis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cis ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cis OCA], [http://pdbe.org/4cis PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cis RCSB], [http://www.ebi.ac.uk/pdbsum/4cis PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cis ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q031W6_LACLS Q031W6_LACLS]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).[HAMAP-Rule:MF_00103][SAAS:SAAS000191_004_120556]
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[https://www.uniprot.org/uniprot/Q031W6_LACLS Q031W6_LACLS] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).[HAMAP-Rule:MF_00103][SAAS:SAAS000191_004_120556]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Streptococcus hollandicus scholl 1891]]
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[[Category: Lactococcus cremoris]]
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[[Category: DNA-formamidopyrimidine glycosylase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Blank, I D]]
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[[Category: Synthetic construct]]
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[[Category: Carell, T]]
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[[Category: Blank ID]]
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[[Category: Flaig, D]]
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[[Category: Carell T]]
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[[Category: Ochsenfeld, C]]
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[[Category: Flaig D]]
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[[Category: Sadeghian, K]]
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[[Category: Ochsenfeld C]]
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[[Category: Schneider, S]]
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[[Category: Sadeghian K]]
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[[Category: Stathis, D]]
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[[Category: Schneider S]]
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[[Category: Strasser, R]]
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[[Category: Stathis D]]
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[[Category: Winnacker, M]]
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[[Category: Strasser R]]
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[[Category: Base excision repair]]
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[[Category: Winnacker M]]
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[[Category: Dna repair]]
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[[Category: Hydrolase]]
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Current revision

Structure of MutM in complex with carbocyclic 8-oxo-G containing DNA

PDB ID 4cis

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