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4css

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==Crystal structure of FimH in complex with a sulfonamide biphenyl alpha D-mannoside==
==Crystal structure of FimH in complex with a sulfonamide biphenyl alpha D-mannoside==
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<StructureSection load='4css' size='340' side='right' caption='[[4css]], [[Resolution|resolution]] 1.07&Aring;' scene=''>
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<StructureSection load='4css' size='340' side='right'caption='[[4css]], [[Resolution|resolution]] 1.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4css]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CSS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4css]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CSS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CWX:4-(ALPHA-D-MANNOPYRANOSYLOXY)-BIPHENYL-4-METHYL+SULFONAMIDE'>CWX</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.069&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cst|4cst]], [[4csy|4csy]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CWX:4-(ALPHA-D-MANNOPYRANOSYLOXY)-BIPHENYL-4-METHYL+SULFONAMIDE'>CWX</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4css FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4css OCA], [http://pdbe.org/4css PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4css RCSB], [http://www.ebi.ac.uk/pdbsum/4css PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4css ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4css FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4css OCA], [https://pdbe.org/4css PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4css RCSB], [https://www.ebi.ac.uk/pdbsum/4css PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4css ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FIMH_ECOLI FIMH_ECOLI]] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.
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[https://www.uniprot.org/uniprot/FIMH_ECOLI FIMH_ECOLI] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4css" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4css" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Adhesin 3D structures|Adhesin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Abgottspon, D]]
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[[Category: Escherichia coli K-12]]
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[[Category: Eris, D]]
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[[Category: Large Structures]]
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[[Category: Ernst, B]]
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[[Category: Abgottspon D]]
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[[Category: Hutter, A]]
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[[Category: Eris D]]
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[[Category: Jakob, R P]]
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[[Category: Ernst B]]
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[[Category: Jian, X]]
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[[Category: Hutter A]]
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[[Category: Kleeb, S]]
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[[Category: Jakob RP]]
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[[Category: Luedin, N]]
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[[Category: Jian X]]
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[[Category: Maier, T]]
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[[Category: Kleeb S]]
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[[Category: Mayer, K]]
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[[Category: Luedin N]]
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[[Category: Navarra, G]]
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[[Category: Maier T]]
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[[Category: Pang, L]]
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[[Category: Mayer K]]
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[[Category: Preston, R C]]
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[[Category: Navarra G]]
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[[Category: Rabbani, S]]
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[[Category: Pang L]]
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[[Category: Scharenberg, M]]
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[[Category: Preston RC]]
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[[Category: Schwardt, O]]
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[[Category: Rabbani S]]
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[[Category: Sharpe, T]]
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[[Category: Scharenberg M]]
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[[Category: Sigl, A]]
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[[Category: Schwardt O]]
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[[Category: Smiesko, M]]
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[[Category: Sharpe T]]
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[[Category: Zihlmann, P]]
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[[Category: Sigl A]]
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[[Category: Adhesin]]
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[[Category: Smiesko M]]
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[[Category: Fimh antagonist]]
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[[Category: Zihlmann P]]
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[[Category: Sugar binding protein]]
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[[Category: Type i pili]]
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[[Category: Upec]]
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[[Category: Uti]]
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Current revision

Crystal structure of FimH in complex with a sulfonamide biphenyl alpha D-mannoside

PDB ID 4css

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