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4d0k
From Proteopedia
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==Complex of Chaetomium thermophilum PAN2 (WD40-CS1) with PAN3 (C-term)== | ==Complex of Chaetomium thermophilum PAN2 (WD40-CS1) with PAN3 (C-term)== | ||
| - | <StructureSection load='4d0k' size='340' side='right' caption='[[4d0k]], [[Resolution|resolution]] 1.89Å' scene=''> | + | <StructureSection load='4d0k' size='340' side='right'caption='[[4d0k]], [[Resolution|resolution]] 1.89Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4d0k]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D0K OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4d0k]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D0K FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d0k OCA], [https://pdbe.org/4d0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d0k RCSB], [https://www.ebi.ac.uk/pdbsum/4d0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d0k ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PAN2_CHATD PAN2_CHATD] Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.[HAMAP-Rule:MF_03182]<ref>PMID:24872509</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Chaetomium thermophilum]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Izaurralde E]] |
| - | [[Category: | + | [[Category: Jonas S]] |
| - | [[Category: | + | [[Category: Weichenrieder O]] |
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Current revision
Complex of Chaetomium thermophilum PAN2 (WD40-CS1) with PAN3 (C-term)
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