This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4pkd

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:23, 20 December 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==U1-70k in complex with U1 snRNA stem-loops 1 and U1-A RRM in complex with stem-loop 2==
==U1-70k in complex with U1 snRNA stem-loops 1 and U1-A RRM in complex with stem-loop 2==
-
<StructureSection load='4pkd' size='340' side='right' caption='[[4pkd]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+
<StructureSection load='4pkd' size='340' side='right'caption='[[4pkd]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4pkd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PKD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PKD FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4pkd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PKD FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3cw1|3cw1]], [[1urn|1urn]], [[3pgw|3pgw]]</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pkd OCA], [https://pdbe.org/4pkd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pkd RCSB], [https://www.ebi.ac.uk/pdbsum/4pkd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pkd ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pkd OCA], [http://pdbe.org/4pkd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pkd RCSB], [http://www.ebi.ac.uk/pdbsum/4pkd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pkd ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/SNRPA_PIG SNRPA_PIG]] Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs (By similarity).
+
[https://www.uniprot.org/uniprot/RU17_HUMAN RU17_HUMAN] Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.[https://www.uniprot.org/uniprot/SNRPA_PIG SNRPA_PIG] Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 24: Line 23:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Kondo, Y]]
+
[[Category: Homo sapiens]]
-
[[Category: Nagai, K]]
+
[[Category: Large Structures]]
-
[[Category: Oubridge, C]]
+
[[Category: Sus scrofa]]
-
[[Category: Roon, A M.van]]
+
[[Category: Kondo Y]]
-
[[Category: Gene regulation]]
+
[[Category: Nagai K]]
-
[[Category: Pre-mrna splicing]]
+
[[Category: Oubridge C]]
-
[[Category: Spliceosome]]
+
[[Category: Van Roon AM]]
-
[[Category: U1 snrnp]]
+
-
[[Category: U1-70k]]
+

Current revision

U1-70k in complex with U1 snRNA stem-loops 1 and U1-A RRM in complex with stem-loop 2

PDB ID 4pkd

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4pkd"
Personal tools