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4tw6

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==The Fk1 domain of FKBP51 in complex with iFit1==
==The Fk1 domain of FKBP51 in complex with iFit1==
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<StructureSection load='4tw6' size='340' side='right' caption='[[4tw6]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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<StructureSection load='4tw6' size='340' side='right'caption='[[4tw6]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4tw6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TW6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4tw6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TW6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=37L:(3-{(1R)-3-(3,4-DIMETHOXYPHENYL)-1-[({(2S)-1-[(2S)-2-(3,4,5-TRIMETHOXYPHENYL)PENT-4-ENOYL]PIPERIDIN-2-YL}CARBONYL)OXY]PROPYL}PHENOXY)ACETIC+ACID'>37L</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=37L:(3-{(1R)-3-(3,4-DIMETHOXYPHENYL)-1-[({(2S)-1-[(2S)-2-(3,4,5-TRIMETHOXYPHENYL)PENT-4-ENOYL]PIPERIDIN-2-YL}CARBONYL)OXY]PROPYL}PHENOXY)ACETIC+ACID'>37L</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tw6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tw6 RCSB], [http://www.ebi.ac.uk/pdbsum/4tw6 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tw6 OCA], [https://pdbe.org/4tw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tw6 RCSB], [https://www.ebi.ac.uk/pdbsum/4tw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tw6 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4tw6" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[FKBP 3D structures|FKBP 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Homo sapiens]]
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[[Category: Almeida, O F.X]]
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[[Category: Large Structures]]
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[[Category: Balsevich, G]]
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[[Category: Almeida OFX]]
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[[Category: Bracher, A]]
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[[Category: Balsevich G]]
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[[Category: Cuboni, S]]
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[[Category: Bracher A]]
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[[Category: Fernandez-Vizarra, P]]
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[[Category: Cuboni S]]
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[[Category: Gaali, S]]
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[[Category: Fernandez-Vizarra P]]
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[[Category: Hartmann, J]]
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[[Category: Gaali S]]
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[[Category: Hausch, F]]
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[[Category: Hartmann J]]
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[[Category: Kirschner, A]]
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[[Category: Hausch F]]
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[[Category: Kozany, C]]
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[[Category: Kirschner A]]
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[[Category: Namendorf, C]]
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[[Category: Kozany C]]
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[[Category: Ruehter, G]]
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[[Category: Namendorf C]]
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[[Category: Schmidt, M V]]
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[[Category: Ruehter G]]
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[[Category: Touma, C]]
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[[Category: Schmidt MV]]
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[[Category: Uhr, M]]
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[[Category: Touma C]]
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[[Category: Fk-506 binding domain]]
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[[Category: Uhr M]]
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[[Category: Hsp90 cochaperone]]
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[[Category: Immunophiline]]
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[[Category: Isomerase]]
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[[Category: Ligand selectivity]]
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[[Category: Peptidyl-prolyl isomerase]]
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Current revision

The Fk1 domain of FKBP51 in complex with iFit1

PDB ID 4tw6

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