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2ki9

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[[Image:2ki9.png|left|200px]]
 
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{{STRUCTURE_2ki9| PDB=2ki9 | SCENE= }}
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==Human cannabinoid receptor-2 helix 6==
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<StructureSection load='2ki9' size='340' side='right'caption='[[2ki9]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ki9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KI9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ki9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ki9 OCA], [https://pdbe.org/2ki9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ki9 RCSB], [https://www.ebi.ac.uk/pdbsum/2ki9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ki9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CNR2_HUMAN CNR2_HUMAN] Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.<ref>PMID:10051546</ref> <ref>PMID:12663043</ref> <ref>PMID:12711605</ref> <ref>PMID:18692962</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We detail the structure and dynamics of a synthetic peptide corresponding to transmembrane helix 6 (TMH6) of human cannabinoid receptor-2 (hCB2) in biomembrane-mimetic environments. The peptide's NMR structural biology is characterized by two alpha-helical domains bridged by a flexible, nonhelical hinge region containing a highly-conserved CWFP motif with an environmentally sensitive, Pro-based conformational switch. Buried within the peptide's flexible region, W(258) may hydrogen-bond with L(255) to help stabilize the Pro-kinked hCB2 TMH6 structure and position C(257) advantageously for interaction with agonist ligands. These characteristics of hCB2 TMH6 are potential structural features of ligand-induced hCB2 activation in vivo.
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===Human cannabinoid receptor-2 helix 6===
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Structural biology of human cannabinoid receptor-2 helix 6 in membrane-mimetic environments.,Tiburu EK, Tyukhtenko S, Deshmukh L, Vinogradova O, Janero DR, Makriyannis A Biochem Biophys Res Commun. 2009 Jun 26;384(2):243-8. Epub 2009 May 3. PMID:19397896<ref>PMID:19397896</ref>
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{{ABSTRACT_PUBMED_19397896}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2ki9" style="background-color:#fffaf0;"></div>
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[[2ki9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KI9 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:019397896</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Deshmukh, L.]]
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[[Category: Homo sapiens]]
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[[Category: Janero, D R.]]
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[[Category: Large Structures]]
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[[Category: Makriyannis, A.]]
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[[Category: Deshmukh L]]
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[[Category: Tiburu, E K.]]
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[[Category: Janero DR]]
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[[Category: Tyukhtenko, S.]]
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[[Category: Makriyannis A]]
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[[Category: Vinogradova, O.]]
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[[Category: Tiburu EK]]
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[[Category: G-protein coupled receptor]]
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[[Category: Tyukhtenko S]]
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[[Category: Gpcr]]
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[[Category: Vinogradova O]]
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[[Category: Human cannabinoid receptor-2]]
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[[Category: Membrane protein]]
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Current revision

Human cannabinoid receptor-2 helix 6

PDB ID 2ki9

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