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2kik

From Proteopedia

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[[Image:2kik.png|left|200px]]
 
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{{STRUCTURE_2kik| PDB=2kik | SCENE= }}
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==An artificial di-iron oxo-protein with phenol oxidase activity==
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<StructureSection load='2kik' size='340' side='right'caption='[[2kik]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kik]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KIK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kik OCA], [https://pdbe.org/2kik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kik RCSB], [https://www.ebi.ac.uk/pdbsum/2kik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kik ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Here we report the de novo design and NMR structure of a four-helical bundle di-iron protein with phenol oxidase activity. The introduction of the cofactor-binding and phenol-binding sites required the incorporation of residues that were detrimental to the free energy of folding of the protein. Sufficient stability was, however, obtained by optimizing the sequence of a loop distant from the active site.
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===An artificial di-iron oxo-protein with phenol oxidase activity===
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An artificial di-iron oxo-protein with phenol oxidase activity.,Faiella M, Andreozzi C, de Rosales RT, Pavone V, Maglio O, Nastri F, DeGrado WF, Lombardi A Nat Chem Biol. 2009 Dec;5(12):882-4. doi: 10.1038/nchembio.257. Epub 2009 Nov 8. PMID:19915535<ref>PMID:19915535</ref>
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{{ABSTRACT_PUBMED_16091937}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2kik" style="background-color:#fffaf0;"></div>
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[[2kik]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KIK OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:016091937</ref><ref group="xtra">PMID:016332076</ref><ref group="xtra">PMID:012655072</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Lombardi, A.]]
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[[Category: Large Structures]]
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[[Category: Maglio, O.]]
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[[Category: Lombardi A]]
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[[Category: De novo design]]
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[[Category: Maglio O]]
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[[Category: De novo protein]]
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[[Category: Diiron protein]]
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[[Category: Four-heix bundle]]
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[[Category: Oxidase]]
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Current revision

An artificial di-iron oxo-protein with phenol oxidase activity

PDB ID 2kik

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OCA

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