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2mlp

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==MICROCIN LEADER PEPTIDE FROM E. COLI, NMR, 25 STRUCTURES==
==MICROCIN LEADER PEPTIDE FROM E. COLI, NMR, 25 STRUCTURES==
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<StructureSection load='2mlp' size='340' side='right' caption='[[2mlp]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
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<StructureSection load='2mlp' size='340' side='right'caption='[[2mlp]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2mlp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MLP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2mlp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MLP FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mlp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mlp OCA], [http://pdbe.org/2mlp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mlp RCSB], [http://www.ebi.ac.uk/pdbsum/2mlp PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mlp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mlp OCA], [https://pdbe.org/2mlp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mlp RCSB], [https://www.ebi.ac.uk/pdbsum/2mlp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mlp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MCBA_ECOLI MCBA_ECOLI]] Affects biofilm formation and mucoidy.<ref>PMID:18309357</ref>
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[https://www.uniprot.org/uniprot/MCBA_ECOLX MCBA_ECOLX] This glycine-rich peptide antibiotic inhibits DNA replication in many enteric bacteria, that leads to induction of the SOS repair system, massive DNA degradation and cell death. B17 inhibits type II topoisomerase by trapping an enzyme - DNA cleavable complex.<ref>PMID:1846808</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Baleja, J D]]
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[[Category: Large Structures]]
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[[Category: Kim, S]]
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[[Category: Baleja JD]]
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[[Category: Roy, R Sinha]]
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[[Category: Kim S]]
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[[Category: Walsh, C T]]
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[[Category: Sinha Roy R]]
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[[Category: Antibiotic]]
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[[Category: Walsh CT]]
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[[Category: Leader peptide]]
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[[Category: Propeptide]]
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MICROCIN LEADER PEPTIDE FROM E. COLI, NMR, 25 STRUCTURES

PDB ID 2mlp

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