1p8j

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[[Image:1p8j.gif|left|200px]]
[[Image:1p8j.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1p8j |SIZE=350|CAPTION= <scene name='initialview01'>1p8j</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1p8j", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAI:DEOXO-METHYLARGININE'>MAI</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Furin Furin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.75 3.4.21.75] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= FURIN OR FUR OR PCSK3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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-->
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|DOMAIN=
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{{STRUCTURE_1p8j| PDB=1p8j | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p8j OCA], [http://www.ebi.ac.uk/pdbsum/1p8j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p8j RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN'''
'''CRYSTAL STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN'''
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[[Category: Lindberg, I.]]
[[Category: Lindberg, I.]]
[[Category: Than, M E.]]
[[Category: Than, M E.]]
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[[Category: chloromethylketone]]
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[[Category: Chloromethylketone]]
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[[Category: p-domain]]
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[[Category: P-domain]]
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[[Category: pace]]
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[[Category: Pace]]
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[[Category: prohormone convertase]]
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[[Category: Prohormone convertase]]
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[[Category: spc1]]
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[[Category: Spc1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:49:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:56:22 2008''
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Revision as of 01:49, 3 May 2008

Image:1p8j.gif

Template:STRUCTURE 1p8j

CRYSTAL STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN


Overview

In eukaryotes, many essential secreted proteins and peptide hormones are excised from larger precursors by members of a class of calcium-dependent endoproteinases, the prohormone-proprotein convertases (PCs). Furin, the best-characterized member of the mammalian PC family, has essential functions in embryogenesis and homeostasis but is also implicated in various pathologies such as tumor metastasis, neurodegeneration and various bacterial and viral diseases caused by such pathogens as anthrax and pathogenic Ebola virus strains. Furin cleaves protein precursors with narrow specificity following basic Arg-Xaa-Lys/Arg-Arg-like motifs. The 2.6 A crystal structure of the decanoyl-Arg-Val-Lys-Arg-chloromethylketone (dec-RVKR-cmk)-inhibited mouse furin ectodomain, the first PC structure, reveals an eight-stranded jelly-roll P domain associated with the catalytic domain. Contoured surface loops shape the active site by cleft, thus explaining furin's stringent requirement for arginine at P1 and P4, and lysine at P2 sites by highly charge-complementary pockets. The structure also explains furin's preference for basic residues at P3, P5 and P6 sites. This structure will aid in the rational design of antiviral and antibacterial drugs.

About this Structure

1P8J is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The crystal structure of the proprotein processing proteinase furin explains its stringent specificity., Henrich S, Cameron A, Bourenkov GP, Kiefersauer R, Huber R, Lindberg I, Bode W, Than ME, Nat Struct Biol. 2003 Jul;10(7):520-6. PMID:12794637 Page seeded by OCA on Sat May 3 04:49:12 2008

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