Thioredoxin Glutathione Reductase
From Proteopedia
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| - | + | <StructureSection load='2x8c' size='350' side='right' scene='43/433645/Cv/2' caption='Thioredoxin glutathione reductase with cofactor FAD dimer complex with triethylene glycol [[2x8c]]'> | |
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== Function == | == Function == | ||
[[Thioredoxin Glutathione Reductase]] (TGR) is an enzyme which bridges two detoxification pathways<ref>PMID:21782895</ref>. It is composed of a small glutaredoxin domain at the N-terminal and a large thioredoxin reductase one at the C-terminal. | [[Thioredoxin Glutathione Reductase]] (TGR) is an enzyme which bridges two detoxification pathways<ref>PMID:21782895</ref>. It is composed of a small glutaredoxin domain at the N-terminal and a large thioredoxin reductase one at the C-terminal. | ||
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== Structural highlights == | == Structural highlights == | ||
| - | The active site of TGR contains | + | The active site of TGR contains <scene name='43/433645/Cv/5'>CXXXXC motif and FAD</scene><ref>PMID:20659890</ref>. |
| + | </StructureSection> | ||
== 3D Structures of Thioredoxin Glutathione Reductase == | == 3D Structures of Thioredoxin Glutathione Reductase == | ||
| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | [[2v6o]], [[2x8c]], [[2x8g]], [[2x8h]] – SmTGR+FAD – ''Schistosoma mansoni''<br /> | + | [[2v6o]], [[2x8c]], [[2x8g]], [[2x8h]], [[2xbi]], [[2xbq]], [[6ftc]] – SmTGR + FAD – ''Schistosoma mansoni''<br /> |
| - | [[2x99]] - SmTGR+FAD+NADPH<br /> | + | [[2x99]] - SmTGR + FAD + NADPH<br /> |
| - | [[3h4k]] - SmTGR+FAD+auranofin<br /> | + | [[3h4k]] - SmTGR + FAD + auranofin<br /> |
| - | [[4la1]] - TGR+FAD – ''Schistosoma japonicum''<br /> | + | [[6rtj]], [[6rtm]], [[6rto]], [[6zlb]], [[6zlp]], [[6zp3]], [[6zst]], [[7b02]], [[7npx]] - SmTGR+FAD + inhibitor<br /> |
| + | [[8a1r]] - SmTGR+FAD + inhibitor – Cryo EM<br /> | ||
| + | [[6fmu]], [[6fmz]], [[6fp4]] - SmTGR + FAD + piperazine derivative<br /> | ||
| + | [[4la1]] - TGR + FAD – ''Schistosoma japonicum''<br /> | ||
| + | [[5w1j]], [[5w1l]] - TGR + FAD - ''Echinococcus granulosus''<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D Structures of Thioredoxin Glutathione Reductase
Updated on 21-December-2023
2v6o, 2x8c, 2x8g, 2x8h, 2xbi, 2xbq, 6ftc – SmTGR + FAD – Schistosoma mansoni
2x99 - SmTGR + FAD + NADPH
3h4k - SmTGR + FAD + auranofin
6rtj, 6rtm, 6rto, 6zlb, 6zlp, 6zp3, 6zst, 7b02, 7npx - SmTGR+FAD + inhibitor
8a1r - SmTGR+FAD + inhibitor – Cryo EM
6fmu, 6fmz, 6fp4 - SmTGR + FAD + piperazine derivative
4la1 - TGR + FAD – Schistosoma japonicum
5w1j, 5w1l - TGR + FAD - Echinococcus granulosus
References
- ↑ Prast-Nielsen S, Huang HH, Williams DL. Thioredoxin glutathione reductase: its role in redox biology and potential as a target for drugs against neglected diseases. Biochim Biophys Acta. 2011 Dec;1810(12):1262-71. doi:, 10.1016/j.bbagen.2011.06.024. Epub 2011 Jul 14. PMID:21782895 doi:http://dx.doi.org/10.1016/j.bbagen.2011.06.024
- ↑ Song L, Li J, Xie S, Qian C, Wang J, Zhang W, Yin X, Hua Z, Yu C. Thioredoxin glutathione reductase as a novel drug target: evidence from Schistosoma japonicum. PLoS One. 2012;7(2):e31456. doi: 10.1371/journal.pone.0031456. Epub 2012 Feb 22. PMID:22384025 doi:http://dx.doi.org/10.1371/journal.pone.0031456
- ↑ Angelucci F, Dimastrogiovanni D, Boumis G, Brunori M, Miele AE, Saccoccia F, Bellelli A. Mapping the catalytic cycle of Schistosoma mansoni thioredoxin glutathione reductase by x-ray crystallography. J Biol Chem. 2010 Jul 21. PMID:20659890 doi:10.1074/jbc.M110.141960
