This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Thymidylate synthase 3D structures

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:35, 25 December 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
==3D structures of thymidylate synthase==
==3D structures of thymidylate synthase==
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} - For a general description of the protein see [[Thymidylate synthase]]
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
Line 8: Line 8:
**[[1hw3]], [[1hw4]], [[1hzw]], [[1ypv]], [[2onb]], [[4gyh]], [[4h1i]], [[4up1]], [[5x5a]], [[5x69]][[3n5g]], [[4kpw]] - hTS – human<br />
**[[1hw3]], [[1hw4]], [[1hzw]], [[1ypv]], [[2onb]], [[4gyh]], [[4h1i]], [[4up1]], [[5x5a]], [[5x69]][[3n5g]], [[4kpw]] - hTS – human<br />
**[[2rd8]], [[2rda]], [[3egy]], [[3ehi]], [[3eaw]], [[3ebu]], [[3ed7]], [[3edw]], [[3ef9]], [[3ejl]], [[3gg5]], [[3gh0]], [[3gh2]], [[4jef]], [[4o1u]], [[4o1x]], [[5x4w]], [[5x4x]], [[5x4y]], [[6qyq]] – hTS (mutant)<br />
**[[2rd8]], [[2rda]], [[3egy]], [[3ehi]], [[3eaw]], [[3ebu]], [[3ed7]], [[3edw]], [[3ef9]], [[3ejl]], [[3gg5]], [[3gh0]], [[3gh2]], [[4jef]], [[4o1u]], [[4o1x]], [[5x4w]], [[5x4x]], [[5x4y]], [[6qyq]] – hTS (mutant)<br />
-
**[[3ihi]], [[6qyj]] – mTS – mouse<br />
+
**[[3ihi]] – mTS – mouse<br />
**[[4iqb]] – nTS – nematode<br />
**[[4iqb]] – nTS – nematode<br />
 +
**[[6k7q]] – sTS - shrimp<br />
**[[3tms]], [[1tjs]], [[1f4b]], [[2ftq]] – EcTS – ''Escherichia coli''<br />
**[[3tms]], [[1tjs]], [[1f4b]], [[2ftq]] – EcTS – ''Escherichia coli''<br />
**[[1ajm]], [[1bq2]], [[1qqq]], [[1ev5]], [[1ev8]], [[1evf]], [[1evg]], [[1ffl]], [[2g8x]], [[2ftn]] - EcTS (mutant) <br />
**[[1ajm]], [[1bq2]], [[1qqq]], [[1ev5]], [[1ev8]], [[1evf]], [[1evg]], [[1ffl]], [[2g8x]], [[2ftn]] - EcTS (mutant) <br />
Line 20: Line 21:
**[[3v8h]] – TS – ''Burkholderia thailandensis''<br />
**[[3v8h]] – TS – ''Burkholderia thailandensis''<br />
**[[4h0r]] - CgTS – ''Corynebacterium glutamicum''<br />
**[[4h0r]] - CgTS – ''Corynebacterium glutamicum''<br />
 +
**[[7ta9]] – TS – ''Acinetobacter baumannii''<br />
**[[4xse]] - VvTS – Varicella-zoster virus<br />
**[[4xse]] - VvTS – Varicella-zoster virus<br />
**[[6auj]] - TS – ''Elizabethkingia anophelis''<br />
**[[6auj]] - TS – ''Elizabethkingia anophelis''<br />
 +
**[[7cc8]] - wssvTS – white spot syndrome virus<br />
 +
**[[5h38]] – hhvORF70 – human herpesvirus 8<br />
-
*Thymidylate synthase binary complex
+
*Thymidylate synthase binary complex with UMP
**[[6qsh]] - hTS + dUMP<br />
**[[6qsh]] - hTS + dUMP<br />
Line 29: Line 33:
**[[6qxg]] - hTS + fluoro-dUMP<br />
**[[6qxg]] - hTS + fluoro-dUMP<br />
**[[3h9k]] - hTS (mutant) + fluoro-dUMP
**[[3h9k]] - hTS (mutant) + fluoro-dUMP
 +
**[[4e5o]] - mTS + UMP<br />
 +
**[[4irr]], [[4isw]] – nTS + UMP<br />
 +
**[[5by6]] – TwTS + UMP – Trichina worm<br />
 +
**[[6k7r]] – sTS + UMP<br />
 +
**[[1tdc]], [[1thy]], [[2tdm]], [[5x5d]] – LcTS + UMP<BR />
 +
**[[1tsv]], [[1tsx]], [[1tsy]], [[1njd]], [[1njb]], [[1vza]], [[1vzb]], [[1jmf]], [[1jmg]], [[1jmh]], [[1jmi]], [[1bo7]], [[1bo8]], [[1bp6]], [[1bpj]], [[1bp0]], [[2g86]], [[2g89]], [[2g8a]], [[2g8d]] - LcTS (mutant) + UMP<BR />
 +
**[[1tdb]] - LcTS + fluoro-UMP<BR />
 +
**[[1vzc]] - LcTS (mutant) + fluoro-UMP<BR />
 +
**[[1bid]] - EcTS + UMP<BR />
 +
**[[2vet]] - EcTS (mutant) + UMP<BR />
 +
**[[3b9h]] - EcTS + nitro-UMP<BR />
 +
**[[3bfi]] - EcTS (mutant) + nitro-UMP<BR />
 +
**[[4dq1]] - TS + UMP – ''Staphylococcus aureus''<br />
 +
**[[6qya]] – EfTS + dUMP – ''Enterococcus faecalis''<br />
 +
**[[4foa]] - MtTS + fluoro-UMP – ''Mycobacterium tuberculosis''<br />
 +
**[[4h0u]] – CgTS + UMP<br />
 +
**[[7dp6]] – BmaTS (mutant) + UMP – ''Brugia malayi''<br />
 +
**[[4xsc]] - VvTS + d-Uridine derivative <br />
 +
**[[4xsd]] - VvTS + dUMP<br />
 +
**[[5h39]] – hhvORF70 + UMP<br />
 +
**[[7xyj]] – wssvORF70 + UMP<br />
 +
 +
*Thymidylate synthase binary complex without UMP
 +
**[[5wrn]] - hTS + CMP<br />
**[[5wrn]] - hTS + CMP<br />
**[[3ob7]] - hTS (mutant) + glutathione<br />
**[[3ob7]] - hTS (mutant) + glutathione<br />
Line 37: Line 65:
**[[4e28]] - hTS + inhibitor<br />
**[[4e28]] - hTS + inhibitor<br />
**[[6r2e]] – hTS (mutant) + folate derivative<br />
**[[6r2e]] – hTS (mutant) + folate derivative<br />
-
**[[4e5o]] - mTS + UMP<br />
 
**[[4ein]] – mTS + substrate analog<br />
**[[4ein]] – mTS + substrate analog<br />
-
**[[4ez8]] – mTS + substrate analog + dihydrofolate<br />
+
**[[6gyj]] - mTS + phenolphthalein<br />
**[[4psg]] – nTS + inhibitor <br >
**[[4psg]] – nTS + inhibitor <br >
-
**[[4irr]], [[4isw]] – nTS + UMP<br />
 
-
**[[5by6]] – TwTS + UMP – Trichina worm<br />
 
**[[1tmk]] - TS + TMP – yeast<br />
**[[1tmk]] - TS + TMP – yeast<br />
-
**[[1tdc]], [[1thy]], [[2tdm]], [[5x5d]] – LcTS + UMP<BR />
 
-
**[[1tsv]], [[1tsx]], [[1tsy]], [[1njd]], [[1njb]], [[1vza]], [[1vzb]], [[1jmf]], [[1jmg]], [[1jmh]], [[1jmi]], [[1bo7]], [[1bo8]], [[1bp6]], [[1bpj]], [[1bp0]], [[2g86]], [[2g89]], [[2g8a]], [[2g8d]] - LcTS (mutant) + UMP<BR />
 
-
**[[1vzc]] - LcTS (mutant) + fluoro-UMP<BR />
 
-
**[[1nja]], [[1njc]] - LcTS (mutant) + CMP<BR />
 
**[[1nje]] - LcTS + CMP<BR />
**[[1nje]] - LcTS + CMP<BR />
-
**[[1tdb]] - LcTS + fluoro-UMP<BR />
+
**[[1nja]], [[1njc]] - LcTS (mutant) + CMP<BR />
**[[1tsl]], [[1tsm]] - LcTS + inhibitor<br />
**[[1tsl]], [[1tsm]] - LcTS + inhibitor<br />
-
**[[4tmk]], [[5tmp]] - EcTS + inhibitor<br />
+
**[[4tmk]], [[5tmp]], [[1an5]] - EcTS + inhibitor<br />
-
**[[1an5]] - EcTS + inhibitor<br />
+
**[[1fwm]] - EcTS (mutant) + inhibitor<br />
**[[1fwm]] - EcTS (mutant) + inhibitor<br />
-
**[[1bid]] - EcTS + UMP<BR />
+
**[[1aob]], [[1bdu]], [[6nnr]] - EcTS + deoxyuridine derivative<br />
-
**[[1aob]], [[1bdu]] - EcTS + deoxyuridine derivative<br />
+
**[[1f4c]], [[1f4e]] - EcTS + tosyl-proline derivative<br />
**[[1f4c]], [[1f4e]] - EcTS + tosyl-proline derivative<br />
**[[1f4d]] - EcTS (mutant) + tosyl-proline derivative<br />
**[[1f4d]] - EcTS (mutant) + tosyl-proline derivative<br />
**[[1f4f]], [[1f4g]] - EcTS + glutamyl-proline derivative<br />
**[[1f4f]], [[1f4g]] - EcTS + glutamyl-proline derivative<br />
-
**[[2vet]] - EcTS (mutant) + UMP<BR />
+
**[[3uwl]] – EfTS + 5-formyl tetrahydrofolate<br />
-
**[[3b9h]] - EcTS + nitro-UMP<BR />
+
-
**[[3bfi]] - EcTS (mutant) + nitro-UMP<BR />
+
-
**[[4dq1]] - TS + UMP – ''Staphylococcus aureus''<br />
+
-
**[[3uwl]] – EfTS + 5-formyl tetrahydrofolate – ''Enterococcus faecalis''<br >
+
-
**[[6qya]] – EfTS + dUMP<br />
+
**[[5j7w]] – EfTS + drug <br >
**[[5j7w]] – EfTS + drug <br >
-
**[[4foa]] - MtTS + fluoro-UMP – ''Mycobacterium tuberculosis''<br />
 
-
**[[4h0u]] – CgTS + UMP<br />
 
-
**[[4xsc]] - VvTS + d-Uridine derivative <br />
 
-
**[[4xsd]] - VvTS + dUMP<br />
 
-
*Thymidylate synthase ternary complex
+
*Thymidylate synthase ternary complex with UMP
-
**[[1hvy]], [[1i00]], [[5x5q]], [[5x66]], [[5x67]] - hTS + drug + UMP<br />
+
**[[1hvy]], [[1i00]], [[5x5q]], [[5x66]], [[5x67]], [[6zxo]] - hTS + drug + UMP<br />
-
**[[1e2d]], [[1e2e]], [[1e2f]] - hTS (mutant) + ADP + TMP<br />
+
**[[5hs3]], [[6pf6]], [[6pf5]], [[6pf4]], [[6pf3]], [[6ojv]], [[6oju]] - hTS + inhibitor + dUMP<br />
**[[5hs3]], [[6pf6]], [[6pf5]], [[6pf4]], [[6pf3]], [[6ojv]], [[6oju]] - hTS + inhibitor + dUMP<br />
**[[1ju6]], [[1juj]] - hTS (mutant) + inhibitor + UMP<br />
**[[1ju6]], [[1juj]] - hTS (mutant) + inhibitor + UMP<br />
**[[5fct]] - mTS + inhibitor + fluoro-UMP <br />
**[[5fct]] - mTS + inhibitor + fluoro-UMP <br />
-
**[[4eb4]] - mTS + drug + UMP<br />
+
**[[4eb4]], [[6y08]] - mTS + drug + UMP<br />
-
**[[6f6z]] - mTS + folate derivative + CMP derivative <br />
+
**[[6gko]] - mTS + phenolphthalein + UMP<br />
**[[1rts]], [[2tsr]] - TS + drug + UMP – rat<br />
**[[1rts]], [[2tsr]] - TS + drug + UMP – rat<br />
-
**[[4iqq]] – nTS + UMP + drug<br />
+
**[[6k7s]] – sTS + UMP + drug<br />
**[[5noo]] - TS + drug + UMP – ''Caenorhabditis elegans''<br />
**[[5noo]] - TS + drug + UMP – ''Caenorhabditis elegans''<br />
-
**[[5m4z]] - TwTS + folate derivative + CMP derivative <br />
+
**[[2tdd]] - LcTS + inhibitor + fluoro-UMP<BR />
-
**[[2tdd]] - LcTS + inhibitor+ fluoro-UMP<BR />
+
**[[1vzd]] - LcTS (mutant) + inhibitor + fluoro-UMP<BR />
-
**[[1vzd]] - LcTS (mutant) + inhibitor+ fluoro-UMP<BR />
+
**[[1vze]], [[1tvu]], [[1tvv]], [[1tvw]] - LcTS (mutant) + inhibitor + UMP<BR />
-
**[[1vze]], [[1tvu]], [[1tvv]], [[1tvw]] - LcTS (mutant) + inhibitor+ UMP<BR />
+
**[[1lca]], [[1lce]], [[3bnz]] - LcTS + inhibitor + UMP<BR />
-
**[[1lca]], [[1lce]], [[3bnz]] - LcTS + inhibitor+ UMP<BR />
+
-
**[[1lcb]] - LcTS + inhibitor+ TMP<BR />
+
**[[3byx]], [[3bz0]], [[3c06]], [[3c0a]], [[3ijz]], [[3ik0]], [[3ik1]] - LcTS + phthalimidic derivative + UMP<BR />
**[[3byx]], [[3bz0]], [[3c06]], [[3c0a]], [[3ijz]], [[3ik0]], [[3ik1]] - LcTS + phthalimidic derivative + UMP<BR />
-
**[[1tys]] - EcTS + inhibitor+ TMP<BR />
+
**[[2bbq]], [[2tsc]], [[1kce]], [[1trg]], [[1kzi]], [[4isk]], [[4lrr]], [[1syn]], [[1tsd]], [[1jtq]], [[1jtu]], [[1jut]], [[1jg0]], [[2a9w]] - EcTS + inhibitor + UMP<BR />
-
**[[2fto]], [[3bgx]] - EcTS (mutant) + inhibitor+ TMP<BR />
+
**[[1zpr]], [[1aiq]], [[1dna]], [[1bq1]], [[1kzj]], [[2vf0]], [[3b5b]], [[1nce]] - EcTS (mutant) + inhibitor + UMP<BR />
-
**[[1tlc]] - EcTS + inhibitor+ GMP<BR />
+
**[[1tls]], [[1tsn]] - EcTS + inhibitor + fluoro-UMP<BR />
-
**[[1syn]], [[1tsd]] - EcTS + inhibitor+ UMP<BR />
+
**[[3bhl]], [[3bhr]] - EcTS + inhibitor + nitro-UMP<BR />
-
**[[2bbq]], [[2tsc]], [[1kce]], [[1trg]], [[1kzi]], [[4isk]], [[4lrr]] - EcTS + inhibitor+ UMP<BR />
+
**[[1bjg]] - EcTS (mutant) + inhibitor + fluoro-UMP<BR />
-
**[[1zpr]], [[1aiq]], [[1dna]], [[1bq1]], [[1kzj]], [[2vf0]], [[3b5b]] - EcTS (mutant) + inhibitor+ UMP<BR />
+
**[[6cdz]] - EcTS (mutant) + deoxyuridine + UMP<br />
-
**[[1tls]], [[1tsn]] - EcTS + inhibitor+ fluoro-UMP<BR />
+
-
**[[3bhl]], [[3bhr]] - EcTS + inhibitor+ nitro-UMP<BR />
+
-
**[[1bjg]] - EcTS (mutant) + inhibitor+ fluoro-UMP<BR />
+
**[[2kce]], [[1axw]] - EcTS + drug + UMP<BR />
**[[2kce]], [[1axw]] - EcTS + drug + UMP<BR />
-
**[[1jtq]], [[1jtu]], [[1jut]], [[1jg0]], [[2a9w]] - EcTS + inhibitor+ UMP<BR />
+
**[[7jxf]] - EcTS + bi-substrate + UMP derivative<BR />
-
**[[1nce]] - EcTS (mutant) + inhibitor+ UMP<BR />
+
**[[7jx1]] - EcTS + bi-substrate + TMP <BR />
**[[1ddu]], [[1tdu]] - EcTS + deoxyuridine derivative + inhibitor<br />
**[[1ddu]], [[1tdu]] - EcTS + deoxyuridine derivative + inhibitor<br />
**[[6cdz]] - EcTS + deoxyuridine + UMP<br />
**[[6cdz]] - EcTS + deoxyuridine + UMP<br />
**[[4gev]] - EcTS + deoxyuridine derivative + cofactor analog<br />
**[[4gev]] - EcTS + deoxyuridine derivative + cofactor analog<br />
**[[6nnr]] - EcTS + deoxyuridine derivative + folate derivative<br />
**[[6nnr]] - EcTS + deoxyuridine derivative + folate derivative<br />
-
**[[1b02]] - BsTS + inhibitor+ fluoro-UMP<BR />
+
**[[1b02]] - BsTS + inhibitor + fluoro-UMP<BR />
-
**[[1ci7]] - PcTS + inhibitor+ UMP – ''Pneumocystis carinii''<br />
+
**[[1ci7]] - PcTS + inhibitor + UMP – ''Pneumocystis carinii''<br />
-
**[[1f28]] - PcTS + inhibitor+ UMP<BR />
+
**[[1f28]] - PcTS + inhibitor + UMP<BR />
-
**[[2aaz]] - TS + inhibitor+ UMP – ''Filobasidiella neoformans''<br />
+
**[[2aaz]] - TS + inhibitor + UMP – ''Filobasidiella neoformans''<br />
**[[3qj7]] - MtTS + spermine + UMP <br />
**[[3qj7]] - MtTS + spermine + UMP <br />
**[[4fog]] - MtTS + fluoro-UMP + methy-DHF<br />
**[[4fog]] - MtTS + fluoro-UMP + methy-DHF<br />
**[[4fox]], [[4fqs]] - MtTS + inhibitor + fluoro-UMP <br />
**[[4fox]], [[4fqs]] - MtTS + inhibitor + fluoro-UMP <br />
-
**[[4o7u]] - EfTS + phthalimidic derivative + folate derivative<br />
 
**[[6qxs]] - EfTS + fluoro-dUMP + folate derivative<br />
**[[6qxs]] - EfTS + fluoro-dUMP + folate derivative<br />
 +
**[[7cca]], [[7xyk]] - wssvTS + UMP + drug<br />
 +
**[[5h3a]] – hhvORF70 + UMP + drug<br />
 +
**[[7dp4]], [[7dp5]] – BmaTS + UMP + drug <br />
 +
 +
*Thymidylate synthase ternary complex without UMP
 +
 +
**[[1e2d]], [[1e2e]], [[1e2f]] - hTS (mutant) + ADP + TMP<br />
 +
**[[6f6z]] - mTS + folate derivative + CMP derivative <br />
 +
**[[4ez8]] – mTS + substrate analog + dihydrofolate<br />
 +
**[[5m4z]] - TwTS + folate derivative + CMP derivative <br />
 +
**[[1lcb]] - LcTS + inhibitor + TMP<BR />
 +
**[[1tys]] - EcTS + inhibitor + TMP<BR />
 +
**[[2fto]], [[3bgx]] - EcTS (mutant) + inhibitor + TMP<BR />
 +
**[[1tlc]] - EcTS + inhibitor + GMP<BR />
 +
**[[4o7u]] - EfTS + phthalimidic derivative + folate derivative<br />
*'''Bifunctional dihydrofolate reductase-thymidylate synthase''' see [[Dihydrofolate reductase]]
*'''Bifunctional dihydrofolate reductase-thymidylate synthase''' see [[Dihydrofolate reductase]]
Line 142: Line 160:
**[[5ioq]], [[5ior]] – TmTS + FAD + d-Uridine derivative<br />
**[[5ioq]], [[5ior]] – TmTS + FAD + d-Uridine derivative<br />
**[[5ios]], [[2iot]] – TmTS (mutant) + FAD + dUMP<br />
**[[5ios]], [[2iot]] – TmTS (mutant) + FAD + dUMP<br />
 +
**[[7ndw]], [[7ndz]] – TmTS + FAD derivative + pteridine derivative<br />
**[[3ge9]] - CgTS<br />
**[[3ge9]] - CgTS<br />
**[[3fnn]] - CgTS + FAD <br />
**[[3fnn]] - CgTS + FAD <br />

Current revision

3D structures of thymidylate synthase

Updated on 25-December-2023 - For a general description of the protein see Thymidylate synthase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Thymidylate_synthase_3D_structures"
Personal tools