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Thymidylate synthase 3D structures
From Proteopedia
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**[[3v8h]] – TS – ''Burkholderia thailandensis''<br /> | **[[3v8h]] – TS – ''Burkholderia thailandensis''<br /> | ||
**[[4h0r]] - CgTS – ''Corynebacterium glutamicum''<br /> | **[[4h0r]] - CgTS – ''Corynebacterium glutamicum''<br /> | ||
| + | **[[7ta9]] – TS – ''Acinetobacter baumannii''<br /> | ||
**[[4xse]] - VvTS – Varicella-zoster virus<br /> | **[[4xse]] - VvTS – Varicella-zoster virus<br /> | ||
**[[6auj]] - TS – ''Elizabethkingia anophelis''<br /> | **[[6auj]] - TS – ''Elizabethkingia anophelis''<br /> | ||
**[[7cc8]] - wssvTS – white spot syndrome virus<br /> | **[[7cc8]] - wssvTS – white spot syndrome virus<br /> | ||
| + | **[[5h38]] – hhvORF70 – human herpesvirus 8<br /> | ||
*Thymidylate synthase binary complex with UMP | *Thymidylate synthase binary complex with UMP | ||
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**[[4foa]] - MtTS + fluoro-UMP – ''Mycobacterium tuberculosis''<br /> | **[[4foa]] - MtTS + fluoro-UMP – ''Mycobacterium tuberculosis''<br /> | ||
**[[4h0u]] – CgTS + UMP<br /> | **[[4h0u]] – CgTS + UMP<br /> | ||
| + | **[[7dp6]] – BmaTS (mutant) + UMP – ''Brugia malayi''<br /> | ||
**[[4xsc]] - VvTS + d-Uridine derivative <br /> | **[[4xsc]] - VvTS + d-Uridine derivative <br /> | ||
**[[4xsd]] - VvTS + dUMP<br /> | **[[4xsd]] - VvTS + dUMP<br /> | ||
| + | **[[5h39]] – hhvORF70 + UMP<br /> | ||
| + | **[[7xyj]] – wssvORF70 + UMP<br /> | ||
*Thymidylate synthase binary complex without UMP | *Thymidylate synthase binary complex without UMP | ||
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*Thymidylate synthase ternary complex with UMP | *Thymidylate synthase ternary complex with UMP | ||
| - | **[[1hvy]], [[1i00]], [[5x5q]], [[5x66]], [[5x67]] - hTS + drug + UMP<br /> | + | **[[1hvy]], [[1i00]], [[5x5q]], [[5x66]], [[5x67]], [[6zxo]] - hTS + drug + UMP<br /> |
**[[5hs3]], [[6pf6]], [[6pf5]], [[6pf4]], [[6pf3]], [[6ojv]], [[6oju]] - hTS + inhibitor + dUMP<br /> | **[[5hs3]], [[6pf6]], [[6pf5]], [[6pf4]], [[6pf3]], [[6ojv]], [[6oju]] - hTS + inhibitor + dUMP<br /> | ||
**[[1ju6]], [[1juj]] - hTS (mutant) + inhibitor + UMP<br /> | **[[1ju6]], [[1juj]] - hTS (mutant) + inhibitor + UMP<br /> | ||
**[[5fct]] - mTS + inhibitor + fluoro-UMP <br /> | **[[5fct]] - mTS + inhibitor + fluoro-UMP <br /> | ||
| - | **[[4eb4]] - mTS + drug + UMP<br /> | + | **[[4eb4]], [[6y08]] - mTS + drug + UMP<br /> |
**[[6gko]] - mTS + phenolphthalein + UMP<br /> | **[[6gko]] - mTS + phenolphthalein + UMP<br /> | ||
**[[1rts]], [[2tsr]] - TS + drug + UMP – rat<br /> | **[[1rts]], [[2tsr]] - TS + drug + UMP – rat<br /> | ||
| - | **[[4iqq]] – nTS + UMP + drug<br /> | ||
**[[6k7s]] – sTS + UMP + drug<br /> | **[[6k7s]] – sTS + UMP + drug<br /> | ||
**[[5noo]] - TS + drug + UMP – ''Caenorhabditis elegans''<br /> | **[[5noo]] - TS + drug + UMP – ''Caenorhabditis elegans''<br /> | ||
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**[[6cdz]] - EcTS (mutant) + deoxyuridine + UMP<br /> | **[[6cdz]] - EcTS (mutant) + deoxyuridine + UMP<br /> | ||
**[[2kce]], [[1axw]] - EcTS + drug + UMP<BR /> | **[[2kce]], [[1axw]] - EcTS + drug + UMP<BR /> | ||
| + | **[[7jxf]] - EcTS + bi-substrate + UMP derivative<BR /> | ||
| + | **[[7jx1]] - EcTS + bi-substrate + TMP <BR /> | ||
**[[1ddu]], [[1tdu]] - EcTS + deoxyuridine derivative + inhibitor<br /> | **[[1ddu]], [[1tdu]] - EcTS + deoxyuridine derivative + inhibitor<br /> | ||
**[[6cdz]] - EcTS + deoxyuridine + UMP<br /> | **[[6cdz]] - EcTS + deoxyuridine + UMP<br /> | ||
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**[[4fox]], [[4fqs]] - MtTS + inhibitor + fluoro-UMP <br /> | **[[4fox]], [[4fqs]] - MtTS + inhibitor + fluoro-UMP <br /> | ||
**[[6qxs]] - EfTS + fluoro-dUMP + folate derivative<br /> | **[[6qxs]] - EfTS + fluoro-dUMP + folate derivative<br /> | ||
| - | **[[7cca]] - wssvTS + UMP + | + | **[[7cca]], [[7xyk]] - wssvTS + UMP + drug<br /> |
| + | **[[5h3a]] – hhvORF70 + UMP + drug<br /> | ||
| + | **[[7dp4]], [[7dp5]] – BmaTS + UMP + drug <br /> | ||
*Thymidylate synthase ternary complex without UMP | *Thymidylate synthase ternary complex without UMP | ||
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**[[5ioq]], [[5ior]] – TmTS + FAD + d-Uridine derivative<br /> | **[[5ioq]], [[5ior]] – TmTS + FAD + d-Uridine derivative<br /> | ||
**[[5ios]], [[2iot]] – TmTS (mutant) + FAD + dUMP<br /> | **[[5ios]], [[2iot]] – TmTS (mutant) + FAD + dUMP<br /> | ||
| + | **[[7ndw]], [[7ndz]] – TmTS + FAD derivative + pteridine derivative<br /> | ||
**[[3ge9]] - CgTS<br /> | **[[3ge9]] - CgTS<br /> | ||
**[[3fnn]] - CgTS + FAD <br /> | **[[3fnn]] - CgTS + FAD <br /> | ||
Current revision
3D structures of thymidylate synthase
Updated on 25-December-2023 - For a general description of the protein see Thymidylate synthase
