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1p9m
From Proteopedia
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[[Image:1p9m.gif|left|200px]] | [[Image:1p9m.gif|left|200px]] | ||
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'''Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex''' | '''Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex''' | ||
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[[Category: Chow, D C.]] | [[Category: Chow, D C.]] | ||
[[Category: Garcia, K C.]] | [[Category: Garcia, K C.]] | ||
| - | [[Category: | + | [[Category: Cytokine]] |
| - | [[Category: | + | [[Category: Four helix bundle]] |
| - | [[Category: | + | [[Category: Gp130]] |
| - | [[Category: | + | [[Category: Ig domain]] |
| - | [[Category: | + | [[Category: Interleukin-6]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:51:15 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 01:51, 3 May 2008
Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex
Overview
Interleukin-6 (IL-6) is an immunoregulatory cytokine that activates a cell-surface signaling assembly composed of IL-6, the IL-6 alpha-receptor (IL-6Ralpha), and the shared signaling receptor gp130. The 3.65 angstrom-resolution structure of the extracellular signaling complex reveals a hexameric, interlocking assembly mediated by a total of 10 symmetry-related, thermodynamically coupled interfaces. Assembly of the hexameric complex occurs sequentially: IL-6 is first engaged by IL-6Ralpha and then presented to gp130in the proper geometry to facilitate a cooperative transition into the high-affinity, signaling-competent hexamer. The quaternary structures of other IL-6/IL-12 family signaling complexes are likely constructed by means of a similar topological blueprint.
About this Structure
1P9M is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex., Boulanger MJ, Chow DC, Brevnova EE, Garcia KC, Science. 2003 Jun 27;300(5628):2101-4. PMID:12829785 Page seeded by OCA on Sat May 3 04:51:15 2008
