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1b4q

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==Solution structure of human thioltransferase complex with glutathione==
==Solution structure of human thioltransferase complex with glutathione==
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<StructureSection load='1b4q' size='340' side='right' caption='[[1b4q]], [[NMR_Ensembles_of_Models | 21 NMR models]]' scene=''>
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<StructureSection load='1b4q' size='340' side='right'caption='[[1b4q]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1b4q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B4Q FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1b4q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B4Q FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b4q OCA], [http://pdbe.org/1b4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b4q RCSB], [http://www.ebi.ac.uk/pdbsum/1b4q PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b4q OCA], [https://pdbe.org/1b4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b4q RCSB], [https://www.ebi.ac.uk/pdbsum/1b4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b4q ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GLRX1_HUMAN GLRX1_HUMAN]] Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
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[https://www.uniprot.org/uniprot/GLRX1_HUMAN GLRX1_HUMAN] Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b4/1b4q_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b4/1b4q_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b4q ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Jao, S C]]
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[[Category: Large Structures]]
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[[Category: Mieyal, J J]]
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[[Category: Jao SC]]
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[[Category: Nanduri, S]]
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[[Category: Mieyal JJ]]
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[[Category: Qin, J]]
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[[Category: Nanduri S]]
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[[Category: Starke, D W]]
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[[Category: Qin J]]
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[[Category: Yang, Y]]
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[[Category: Starke DW]]
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[[Category: Disulfide intermediate]]
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[[Category: Yang Y]]
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[[Category: Glutathione]]
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[[Category: Human thioltransferase]]
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[[Category: Oxidoreductase]]
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Current revision

Solution structure of human thioltransferase complex with glutathione

PDB ID 1b4q

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