This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1b4y
From Proteopedia
(Difference between revisions)
| (7 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:1b4y.png|left|200px]] | ||
| - | + | ==STRUCTURE AND MECHANISM OF FORMATION OF THE H-Y5 ISOMER OF AN INTRAMOLECULAR DNA TRIPLE HELIX.== | |
| + | <StructureSection load='1b4y' size='340' side='right'caption='[[1b4y]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1b4y]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B4Y FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b4y OCA], [https://pdbe.org/1b4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b4y RCSB], [https://www.ebi.ac.uk/pdbsum/1b4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b4y ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | H-DNA, thought to play a regulatory role in transcription, exists in two isomeric forms, H-y3 and H-y5. We present the first solution structure of a DNA fragment representing the H-y5 fold. The structure shows the H-y5 triple helix, and for the first time how in an H-DNA isomer the purine strand extension interacts with the triplex loop. It gives direct insight into the mechanism of H-DNA formation, and explains a host of biochemical and biophysical data on the relative stability of the H-DNA isomers. In addition, the observed interaction of the purine strand extension and the triplex loop provides new clues to the design of clamp-type triple helix-forming oligonucleotides. | ||
| - | + | Structure and mechanism of formation of the H-y5 isomer of an intramolecular DNA triple helix.,van Dongen MJ, Doreleijers JF, van der Marel GA, van Boom JH, Hilbers CW, Wijmenga SS Nat Struct Biol. 1999 Sep;6(9):854-9. PMID:10467098<ref>PMID:10467098</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | == | + | <div class="pdbe-citations 1b4y" style="background-color:#fffaf0;"></div> |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | + | __TOC__ | |
| - | [[Category: Doreleijers | + | </StructureSection> |
| - | [[Category: Hilbers | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Doreleijers JF]] |
| - | [[Category: | + | [[Category: Hilbers CW]] |
| - | [[Category: | + | [[Category: Van Boom JH]] |
| - | [[Category: | + | [[Category: Van Der Marel GA]] |
| - | + | [[Category: Van Dongen MJP]] | |
| + | [[Category: Wijmenga SS]] | ||
Current revision
STRUCTURE AND MECHANISM OF FORMATION OF THE H-Y5 ISOMER OF AN INTRAMOLECULAR DNA TRIPLE HELIX.
| |||||||||||
