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1cd9

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==2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR==
==2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR==
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<StructureSection load='1cd9' size='340' side='right' caption='[[1cd9]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='1cd9' size='340' side='right'caption='[[1cd9]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1cd9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CD9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CD9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1cd9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CD9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CD9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cd9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cd9 OCA], [http://pdbe.org/1cd9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cd9 RCSB], [http://www.ebi.ac.uk/pdbsum/1cd9 PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cd9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cd9 OCA], [https://pdbe.org/1cd9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cd9 RCSB], [https://www.ebi.ac.uk/pdbsum/1cd9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cd9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CSF3_HUMAN CSF3_HUMAN]] Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. [[http://www.uniprot.org/uniprot/CSF3R_MOUSE CSF3R_MOUSE]] Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface.
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[https://www.uniprot.org/uniprot/CSF3R_MOUSE CSF3R_MOUSE] Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/1cd9_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/1cd9_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 1cd9" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1cd9" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Colony-stimulating factor 3D structures|Colony-stimulating factor 3D structures]]
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*[[Colony-stimulating factor receptor 3D structures|Colony-stimulating factor receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Aritomi, M]]
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[[Category: Mus musculus]]
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[[Category: Kunishima, N]]
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[[Category: Aritomi M]]
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[[Category: Kuroki, R]]
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[[Category: Kunishima N]]
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[[Category: Morikawa, K]]
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[[Category: Kuroki R]]
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[[Category: Okamoto, T]]
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[[Category: Morikawa K]]
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[[Category: Ota, Y]]
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[[Category: Okamoto T]]
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[[Category: Class1 cytokine]]
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[[Category: Ota Y]]
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[[Category: Cytokine]]
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[[Category: Hematopoietic receptor]]
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[[Category: Signal transduction]]
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Current revision

2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR

PDB ID 1cd9

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