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1dqs

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Current revision (23:28, 27 December 2023) (edit) (undo)
 
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<StructureSection load='1dqs' size='340' side='right'caption='[[1dqs]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='1dqs' size='340' side='right'caption='[[1dqs]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1dqs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/A._nidulans A. nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DQS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1dqs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_nidulans Aspergillus nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DQS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CRB:[1R-(1ALPHA,3BETA,4ALPHA,5BETA)]-5-(PHOSPHONOMETHYL)-1,3,4-TRIHYDROXYCYCLOHEXANE-1-CARBOXYLIC+ACID'>CRB</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PART OF AROMA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=162425 A. nidulans])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CRB:[1R-(1ALPHA,3BETA,4ALPHA,5BETA)]-5-(PHOSPHONOMETHYL)-1,3,4-TRIHYDROXYCYCLOHEXANE-1-CARBOXYLIC+ACID'>CRB</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/3-dehydroquinate_synthase 3-dehydroquinate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.4 4.2.3.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dqs OCA], [https://pdbe.org/1dqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dqs RCSB], [https://www.ebi.ac.uk/pdbsum/1dqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dqs ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dqs OCA], [https://pdbe.org/1dqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dqs RCSB], [https://www.ebi.ac.uk/pdbsum/1dqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dqs ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ARO1_EMENI ARO1_EMENI]] The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.[HAMAP-Rule:MF_03143]
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[https://www.uniprot.org/uniprot/ARO1_EMENI ARO1_EMENI] The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.[HAMAP-Rule:MF_03143]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 3-dehydroquinate synthase]]
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[[Category: Aspergillus nidulans]]
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[[Category: A. nidulans]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Brown, K A]]
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[[Category: Brown KA]]
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[[Category: Carpenter, E P]]
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[[Category: Carpenter EP]]
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[[Category: Frost, J W]]
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[[Category: Frost JW]]
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[[Category: Hawkins, A R]]
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[[Category: Hawkins AR]]
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[[Category: Aromatic amino acid biosynthesis]]
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[[Category: Cyclase]]
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[[Category: Intra molecular aldol condensation]]
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[[Category: Lyase]]
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[[Category: Multi-step enzyme]]
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[[Category: Nad+ binding]]
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[[Category: Oxidoreductase]]
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[[Category: Phosphate elimination]]
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[[Category: Shikimate pathway enzyme]]
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[[Category: Zn2+ binding]]
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Current revision

CRYSTAL STRUCTURE OF DEHYDROQUINATE SYNTHASE (DHQS) COMPLEXED WITH CARBAPHOSPHONATE, NAD+ AND ZN2+

PDB ID 1dqs

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