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1gg5

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Current revision (23:31, 27 December 2023) (edit) (undo)
 
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<StructureSection load='1gg5' size='340' side='right'caption='[[1gg5]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='1gg5' size='340' side='right'caption='[[1gg5]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1gg5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GG5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1gg5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GG5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E09:3-HYDROXYMETHYL-5-AZIRIDINYL-1METHYL-2-[1H-INDOLE-4,7-DIONE]-PROPANOL'>E09</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/NAD(P)H_dehydrogenase_(quinone) NAD(P)H dehydrogenase (quinone)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.5.2 1.6.5.2] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E09:3-HYDROXYMETHYL-5-AZIRIDINYL-1METHYL-2-[1H-INDOLE-4,7-DIONE]-PROPANOL'>E09</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gg5 OCA], [https://pdbe.org/1gg5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gg5 RCSB], [https://www.ebi.ac.uk/pdbsum/1gg5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gg5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gg5 OCA], [https://pdbe.org/1gg5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gg5 RCSB], [https://www.ebi.ac.uk/pdbsum/1gg5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gg5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/NQO1_HUMAN NQO1_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
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[https://www.uniprot.org/uniprot/NQO1_HUMAN NQO1_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Quinone reductase|Quinone reductase]]
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*[[Quinone reductase 3D structures|Quinone reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Amzel, L M]]
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[[Category: Amzel LM]]
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[[Category: Bianchet, M A]]
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[[Category: Bianchet MA]]
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[[Category: Faig, M]]
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[[Category: Faig M]]
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[[Category: Hargreaves, R]]
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[[Category: Hargreaves R]]
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[[Category: Hudnott, A R]]
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[[Category: Hudnott AR]]
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[[Category: Moody, C J]]
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[[Category: Moody CJ]]
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[[Category: Ross, D]]
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[[Category: Ross D]]
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[[Category: Winski, S]]
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[[Category: Winski S]]
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[[Category: Flavoprotein]]
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[[Category: Oxidoreductase]]
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[[Category: Rossmann fold]]
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Current revision

CRYSTAL STRUCTURE OF A COMPLEX OF HUMAN NAD[P]H-QUINONE OXIDOREDUCTASE AND A CHEMOTHERAPEUTIC DRUG (E09) AT 2.5 A RESOLUTION

PDB ID 1gg5

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