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1iv5

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==New Crystal Form of Human CD81 Large Extracellular Loop.==
==New Crystal Form of Human CD81 Large Extracellular Loop.==
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<StructureSection load='1iv5' size='340' side='right' caption='[[1iv5]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='1iv5' size='340' side='right'caption='[[1iv5]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1iv5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IV5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1iv5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IV5 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g8q|1g8q]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iv5 OCA], [http://pdbe.org/1iv5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1iv5 RCSB], [http://www.ebi.ac.uk/pdbsum/1iv5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1iv5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iv5 OCA], [https://pdbe.org/1iv5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iv5 RCSB], [https://www.ebi.ac.uk/pdbsum/1iv5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iv5 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN]] Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:[http://omim.org/entry/613496 613496]]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:20237408</ref>
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[https://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN] Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:[https://omim.org/entry/613496 613496]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:20237408</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN]] May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.
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[https://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN] May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 1iv5" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1iv5" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[CD81|CD81]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Bolognesi, M]]
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[[Category: Large Structures]]
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[[Category: Fabiana, F]]
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[[Category: Bolognesi M]]
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[[Category: Galli, G]]
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[[Category: Fabiana F]]
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[[Category: Grandi, G]]
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[[Category: Galli G]]
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[[Category: Kitadokoro, K]]
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[[Category: Grandi G]]
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[[Category: Marco, P]]
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[[Category: Kitadokoro K]]
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[[Category: Petracca, R]]
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[[Category: Marco P]]
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[[Category: Alpha domain]]
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[[Category: Petracca R]]
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[[Category: Five helix]]
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[[Category: Immune system]]
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Current revision

New Crystal Form of Human CD81 Large Extracellular Loop.

PDB ID 1iv5

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