1ix1
From Proteopedia
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==Crystal Structure of P.aeruginosa Peptide deformylase Complexed with Antibiotic Actinonin== | ==Crystal Structure of P.aeruginosa Peptide deformylase Complexed with Antibiotic Actinonin== | ||
| - | <StructureSection load='1ix1' size='340' side='right' caption='[[1ix1]], [[Resolution|resolution]] 1.85Å' scene=''> | + | <StructureSection load='1ix1' size='340' side='right'caption='[[1ix1]], [[Resolution|resolution]] 1.85Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1ix1]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1ix1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IX1 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BB2:ACTINONIN'>BB2</scene>, <scene name='pdbligand=MHA:(CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC+ACID'>MHA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | < | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ix1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ix1 OCA], [https://pdbe.org/1ix1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ix1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ix1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ix1 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/DEF_PSEAE DEF_PSEAE] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/1ix1_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/1ix1_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ix1 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Ahn | + | [[Category: Pseudomonas aeruginosa]] |
| - | [[Category: Han | + | [[Category: Ahn HJ]] |
| - | [[Category: Kim | + | [[Category: Han BW]] |
| - | [[Category: Lee | + | [[Category: Kim H-W]] |
| - | [[Category: Lee | + | [[Category: Lee BI]] |
| - | [[Category: Lee | + | [[Category: Lee HH]] |
| - | [[Category: Suh | + | [[Category: Lee JY]] |
| - | [[Category: Yang | + | [[Category: Suh SW]] |
| - | [[Category: Yoon | + | [[Category: Yang JK]] |
| - | + | [[Category: Yoon H-J]] | |
| - | + | ||
Current revision
Crystal Structure of P.aeruginosa Peptide deformylase Complexed with Antibiotic Actinonin
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Categories: Large Structures | Pseudomonas aeruginosa | Ahn HJ | Han BW | Kim H-W | Lee BI | Lee HH | Lee JY | Suh SW | Yang JK | Yoon H-J
