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1iy9

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==Crystal structure of spermidine synthase==
==Crystal structure of spermidine synthase==
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<StructureSection load='1iy9' size='340' side='right' caption='[[1iy9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='1iy9' size='340' side='right'caption='[[1iy9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1iy9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IY9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1iy9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IY9 FirstGlance]. <br>
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Spermidine_synthase Spermidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.16 2.5.1.16] </span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iy9 OCA], [http://pdbe.org/1iy9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1iy9 RCSB], [http://www.ebi.ac.uk/pdbsum/1iy9 PDBsum], [http://www.topsan.org/Proteins/NESGC/1iy9 TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iy9 OCA], [https://pdbe.org/1iy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iy9 RCSB], [https://www.ebi.ac.uk/pdbsum/1iy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iy9 ProSAT], [https://www.topsan.org/Proteins/NESGC/1iy9 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SPEE_BACSU SPEE_BACSU]] Involved in the cell growth and proliferation. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine (Probable).<ref>PMID:9723923</ref>
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[https://www.uniprot.org/uniprot/SPEE_BACSU SPEE_BACSU] Involved in the cell growth and proliferation. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine (Probable).<ref>PMID:9723923</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iy/1iy9_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iy/1iy9_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1iy9 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Spermidine Synthase|Spermidine Synthase]]
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*[[Spermidine synthase 3D structures|Spermidine synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus globigii migula 1900]]
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[[Category: Bacillus subtilis]]
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[[Category: Spermidine synthase]]
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[[Category: Large Structures]]
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[[Category: Acton, T]]
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[[Category: Acton T]]
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[[Category: Hunt, J F]]
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[[Category: Hunt JF]]
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[[Category: Montelione, G]]
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[[Category: Montelione G]]
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[[Category: Structural genomic]]
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[[Category: Rost B]]
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[[Category: Rost, B]]
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[[Category: Shen J]]
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[[Category: Shen, J]]
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[[Category: Smith PC]]
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[[Category: Smith, P C]]
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[[Category: Tan AY]]
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[[Category: Tan, A Y]]
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[[Category: Xiao R]]
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[[Category: Xiao, R]]
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[[Category: Nesg]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Rossmann fold]]
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[[Category: Transferase]]
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Current revision

Crystal structure of spermidine synthase

PDB ID 1iy9

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