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1iyw

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==Preliminary Structure of Thermus thermophilus Ligand-Free Valyl-tRNA Synthetase==
==Preliminary Structure of Thermus thermophilus Ligand-Free Valyl-tRNA Synthetase==
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<StructureSection load='1iyw' size='340' side='right' caption='[[1iyw]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
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<StructureSection load='1iyw' size='340' side='right'caption='[[1iyw]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1iyw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IYW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IYW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1iyw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IYW FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gax|1gax]], [[1ivs|1ivs]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Valine--tRNA_ligase Valine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.9 6.1.1.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iyw OCA], [https://pdbe.org/1iyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iyw RCSB], [https://www.ebi.ac.uk/pdbsum/1iyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iyw ProSAT], [https://www.topsan.org/Proteins/RSGI/1iyw TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iyw OCA], [http://pdbe.org/1iyw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1iyw RCSB], [http://www.ebi.ac.uk/pdbsum/1iyw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1iyw ProSAT], [http://www.topsan.org/Proteins/RSGI/1iyw TOPSAN]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SYV_THETH SYV_THETH]] Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a "posttransfer" editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.[HAMAP-Rule:MF_02004]
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[https://www.uniprot.org/uniprot/SYV_THETH SYV_THETH] Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a "posttransfer" editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.[HAMAP-Rule:MF_02004]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 1iyw" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1iyw" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
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[[Category: Large Structures]]
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[[Category: Valine--tRNA ligase]]
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[[Category: Thermus thermophilus]]
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[[Category: Fukai, S]]
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[[Category: Fukai S]]
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[[Category: Nureki, O]]
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[[Category: Nureki O]]
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[[Category: Structural genomic]]
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[[Category: Sekine S]]
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[[Category: Sekine, S]]
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[[Category: Shimada A]]
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[[Category: Shimada, A]]
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[[Category: Vassylyev DG]]
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[[Category: Vassylyev, D G]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Ligase]]
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[[Category: Rossmann fold]]
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[[Category: Rsgi]]
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Current revision

Preliminary Structure of Thermus thermophilus Ligand-Free Valyl-tRNA Synthetase

PDB ID 1iyw

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