1j0s

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[[Image:1j0s.png|left|200px]]
 
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{{STRUCTURE_1j0s| PDB=1j0s | SCENE= }}
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==Solution structure of the human interleukin-18==
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<StructureSection load='1j0s' size='340' side='right'caption='[[1j0s]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1j0s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J0S FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j0s OCA], [https://pdbe.org/1j0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j0s RCSB], [https://www.ebi.ac.uk/pdbsum/1j0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j0s ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IL18_HUMAN IL18_HUMAN] Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j0/1j0s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j0s ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Interleukin-18 (IL-18), a cytokine formerly known as interferon-gamma- (IFN-gamma-) inducing factor, has pleiotropic immunoregulatory functions, including augmentation of IFN-gamma production, Fas-mediated cytotoxicity and developmental regulation of T-lymphocyte helper type I. We determined the solution structure of IL-18 as a first step toward understanding its receptor activation mechanism. It folds into a beta-trefoil structure that resembles that of IL-1. Extensive mutagenesis revealed the presence of three sites that are important for receptor activation: two serve as binding sites for IL-18 receptor alpha (IL-18Ralpha), located at positions similar to those of IL-1 for IL-1 receptor type I (IL-1RI), whereas the third site may be involved in IL-18 receptor beta (IL-18Rbeta) binding. The structure and mutagenesis data provide a basis for understanding the IL-18-induced heterodimerization of receptor subunits, which is necessary for receptor activation.
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===Solution structure of the human interleukin-18===
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The structure and binding mode of interleukin-18.,Kato Z, Jee J, Shikano H, Mishima M, Ohki I, Ohnishi H, Li A, Hashimoto K, Matsukuma E, Omoya K, Yamamoto Y, Yoneda T, Hara T, Kondo N, Shirakawa M Nat Struct Biol. 2003 Nov;10(11):966-71. Epub 2003 Oct 5. PMID:14528293<ref>PMID:14528293</ref>
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{{ABSTRACT_PUBMED_14528293}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1j0s" style="background-color:#fffaf0;"></div>
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[[1j0s]] is a 1 chain structure of [[Interleukin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J0S OCA].
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==See Also==
==See Also==
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*[[Interleukin|Interleukin]]
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:014528293</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hara, T.]]
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[[Category: Large Structures]]
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[[Category: Jee, J.]]
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[[Category: Hara T]]
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[[Category: Kato, Z.]]
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[[Category: Jee J]]
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[[Category: Kondo, N.]]
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[[Category: Kato Z]]
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[[Category: Mishima, M.]]
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[[Category: Kondo N]]
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[[Category: Ohki, I.]]
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[[Category: Mishima M]]
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[[Category: Shikano, H.]]
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[[Category: Ohki I]]
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[[Category: Shirakawa, M.]]
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[[Category: Shikano H]]
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[[Category: Torigoe, K.]]
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[[Category: Shirakawa M]]
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[[Category: Yoneda, T.]]
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[[Category: Torigoe K]]
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[[Category: Beta trefoil]]
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[[Category: Yoneda T]]
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[[Category: Cytokine]]
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Current revision

Solution structure of the human interleukin-18

PDB ID 1j0s

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