1j0s

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(New page: 200px<br /> <applet load="1j0s" size="450" color="white" frame="true" align="right" spinBox="true" caption="1j0s" /> '''Solution structure of the human interleukin...)
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[[Image:1j0s.gif|left|200px]]<br />
 
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<applet load="1j0s" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1j0s" />
 
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'''Solution structure of the human interleukin-18'''<br />
 
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==Overview==
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==Solution structure of the human interleukin-18==
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Interleukin-18 (IL-18), a cytokine formerly known as interferon-gamma-, (IFN-gamma-) inducing factor, has pleiotropic immunoregulatory functions, including augmentation of IFN-gamma production, Fas-mediated cytotoxicity, and developmental regulation of T-lymphocyte helper type I. We determined, the solution structure of IL-18 as a first step toward understanding its, receptor activation mechanism. It folds into a beta-trefoil structure that, resembles that of IL-1. Extensive mutagenesis revealed the presence of, three sites that are important for receptor activation: two serve as, binding sites for IL-18 receptor alpha (IL-18Ralpha), located at positions, similar to those of IL-1 for IL-1 receptor type I (IL-1RI), whereas the, third site may be involved in IL-18 receptor beta (IL-18Rbeta) binding., The structure and mutagenesis data provide a basis for understanding the, IL-18-induced heterodimerization of receptor subunits, which is necessary, for receptor activation.
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<StructureSection load='1j0s' size='340' side='right'caption='[[1j0s]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1j0s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J0S FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j0s OCA], [https://pdbe.org/1j0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j0s RCSB], [https://www.ebi.ac.uk/pdbsum/1j0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j0s ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IL18_HUMAN IL18_HUMAN] Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j0/1j0s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j0s ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Interleukin-18 (IL-18), a cytokine formerly known as interferon-gamma- (IFN-gamma-) inducing factor, has pleiotropic immunoregulatory functions, including augmentation of IFN-gamma production, Fas-mediated cytotoxicity and developmental regulation of T-lymphocyte helper type I. We determined the solution structure of IL-18 as a first step toward understanding its receptor activation mechanism. It folds into a beta-trefoil structure that resembles that of IL-1. Extensive mutagenesis revealed the presence of three sites that are important for receptor activation: two serve as binding sites for IL-18 receptor alpha (IL-18Ralpha), located at positions similar to those of IL-1 for IL-1 receptor type I (IL-1RI), whereas the third site may be involved in IL-18 receptor beta (IL-18Rbeta) binding. The structure and mutagenesis data provide a basis for understanding the IL-18-induced heterodimerization of receptor subunits, which is necessary for receptor activation.
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==About this Structure==
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The structure and binding mode of interleukin-18.,Kato Z, Jee J, Shikano H, Mishima M, Ohki I, Ohnishi H, Li A, Hashimoto K, Matsukuma E, Omoya K, Yamamoto Y, Yoneda T, Hara T, Kondo N, Shirakawa M Nat Struct Biol. 2003 Nov;10(11):966-71. Epub 2003 Oct 5. PMID:14528293<ref>PMID:14528293</ref>
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1J0S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1J0S OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The structure and binding mode of interleukin-18., Kato Z, Jee J, Shikano H, Mishima M, Ohki I, Ohnishi H, Li A, Hashimoto K, Matsukuma E, Omoya K, Yamamoto Y, Yoneda T, Hara T, Kondo N, Shirakawa M, Nat Struct Biol. 2003 Nov;10(11):966-71. Epub 2003 Oct 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14528293 14528293]
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</div>
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[[Category: Homo sapiens]]
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<div class="pdbe-citations 1j0s" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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[[Category: Hara, T.]]
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[[Category: Jee, J.]]
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[[Category: Kato, Z.]]
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[[Category: Kondo, N.]]
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[[Category: Mishima, M.]]
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[[Category: Ohki, I.]]
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[[Category: Shikano, H.]]
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[[Category: Shirakawa, M.]]
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[[Category: Torigoe, K.]]
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[[Category: Yoneda, T.]]
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[[Category: beta trefoil]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:36:15 2007''
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==See Also==
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Hara T]]
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[[Category: Jee J]]
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[[Category: Kato Z]]
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[[Category: Kondo N]]
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[[Category: Mishima M]]
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[[Category: Ohki I]]
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[[Category: Shikano H]]
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[[Category: Shirakawa M]]
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[[Category: Torigoe K]]
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[[Category: Yoneda T]]

Current revision

Solution structure of the human interleukin-18

PDB ID 1j0s

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