This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1j48
From Proteopedia
(Difference between revisions)
| (7 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:1j48.png|left|200px]] | ||
| - | + | ==Crystal Structure of Apo-C1027== | |
| - | + | <StructureSection load='1j48' size='340' side='right'caption='[[1j48]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1j48]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_globisporus Streptomyces globisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J48 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J48 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j48 OCA], [https://pdbe.org/1j48 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j48 RCSB], [https://www.ebi.ac.uk/pdbsum/1j48 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j48 ProSAT]</span></td></tr> |
| - | [[1j48]] is a 2 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CAGA_STRGL CAGA_STRGL] Binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j4/1j48_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j48 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Streptomyces globisporus]] | [[Category: Streptomyces globisporus]] | ||
| - | [[Category: Bartlam | + | [[Category: Bartlam M]] |
| - | [[Category: Chen | + | [[Category: Chen Y]] |
| - | [[Category: Gao | + | [[Category: Gao Y]] |
| - | [[Category: Jin | + | [[Category: Jin L]] |
| - | [[Category: Li | + | [[Category: Li J]] |
| - | [[Category: Liu | + | [[Category: Liu Y]] |
| - | [[Category: Rao | + | [[Category: Rao Z]] |
| - | [[Category: Shao | + | [[Category: Shao Y]] |
| - | [[Category: Tang | + | [[Category: Tang H]] |
| - | [[Category: Zhen | + | [[Category: Zhen Y]] |
| - | + | ||
| - | + | ||
Current revision
Crystal Structure of Apo-C1027
| |||||||||||
Categories: Large Structures | Streptomyces globisporus | Bartlam M | Chen Y | Gao Y | Jin L | Li J | Liu Y | Rao Z | Shao Y | Tang H | Zhen Y
