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1o5p

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==Solution Structure of holo-Neocarzinostatin==
==Solution Structure of holo-Neocarzinostatin==
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<StructureSection load='1o5p' size='340' side='right' caption='[[1o5p]], [[NMR_Ensembles_of_Models | 60 NMR models]]' scene=''>
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<StructureSection load='1o5p' size='340' side='right'caption='[[1o5p]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1o5p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_carzinostaticus Streptomyces carzinostaticus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O5P FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1o5p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_carzinostaticus Streptomyces carzinostaticus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O5P FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CHR:NEOCARZINOSTATIN-CHROMOPHORE'>CHR</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o5p OCA], [http://pdbe.org/1o5p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o5p RCSB], [http://www.ebi.ac.uk/pdbsum/1o5p PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CHR:NEOCARZINOSTATIN-CHROMOPHORE'>CHR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o5p OCA], [https://pdbe.org/1o5p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o5p RCSB], [https://www.ebi.ac.uk/pdbsum/1o5p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o5p ProSAT]</span></td></tr>
</table>
</table>
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{{Large structure}}
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NCZS_STRCZ NCZS_STRCZ]] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.
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[https://www.uniprot.org/uniprot/NCZS_STRCZ NCZS_STRCZ] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o5/1o5p_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o5/1o5p_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptomyces carzinostaticus]]
[[Category: Streptomyces carzinostaticus]]
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[[Category: Hasuda, K]]
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[[Category: Hasuda K]]
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[[Category: Ishino, T]]
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[[Category: Ishino T]]
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[[Category: Kobayashi, Y]]
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[[Category: Kobayashi Y]]
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[[Category: Ohkubo, T]]
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[[Category: Ohkubo T]]
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[[Category: Takashima, H]]
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[[Category: Takashima H]]
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[[Category: Yoshida, T]]
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[[Category: Yoshida T]]
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[[Category: Stranded beta barrel]]
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[[Category: Antibiotic]]
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[[Category: Cromoprotein]]
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[[Category: Protein-ligand complex]]
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Current revision

Solution Structure of holo-Neocarzinostatin

PDB ID 1o5p

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