1uc2

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[[Image:1uc2.gif|left|200px]]
 
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{{Structure
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==Hypothetical Extein Protein of PH1602 from Pyrococcus horikoshii==
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|PDB= 1uc2 |SIZE=350|CAPTION= <scene name='initialview01'>1uc2</scene>, resolution 2.15&Aring;
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<StructureSection load='1uc2' size='340' side='right'caption='[[1uc2]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SUC:SUCROSE'>SUC</scene> and <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
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<table><tr><td colspan='2'>[[1uc2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UC2 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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|GENE= PH1602_extein ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus horikoshii])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FRU:FRUCTOSE'>FRU</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900003:sucrose'>PRD_900003</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uc2 OCA], [https://pdbe.org/1uc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uc2 RCSB], [https://www.ebi.ac.uk/pdbsum/1uc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uc2 ProSAT]</span></td></tr>
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</table>
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'''Hypothetical Extein Protein of PH1602 from Pyrococcus horikoshii'''
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== Function ==
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[https://www.uniprot.org/uniprot/RTCB_PYRHO RTCB_PYRHO] tRNA-splicing ligase that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs (By similarity).
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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1UC2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UC2 OCA].
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Check<jmol>
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<jmolCheckbox>
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==Reference==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uc/1uc2_consurf.spt"</scriptWhenChecked>
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Crystal structure of an RtcB homolog protein (PH1602-extein protein) from Pyrococcus horikoshii reveals a novel fold., Okada C, Maegawa Y, Yao M, Tanaka I, Proteins. 2006 Jun 1;63(4):1119-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16485279 16485279]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uc2 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Pyrococcus horikoshii]]
[[Category: Pyrococcus horikoshii]]
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[[Category: Single protein]]
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[[Category: Maegawa Y]]
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[[Category: Maegawa, Y.]]
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[[Category: Okada C]]
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[[Category: Okada, C.]]
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[[Category: Tanaka I]]
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[[Category: Tanaka, I.]]
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[[Category: Yao M]]
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[[Category: Yao, M.]]
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[[Category: SO4]]
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[[Category: SUC]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:30:02 2008''
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Current revision

Hypothetical Extein Protein of PH1602 from Pyrococcus horikoshii

PDB ID 1uc2

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