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1udu

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==Crystal structure of Human Phosphodiesterase 5 complexed with tadalafil(Cialis)==
==Crystal structure of Human Phosphodiesterase 5 complexed with tadalafil(Cialis)==
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<StructureSection load='1udu' size='340' side='right' caption='[[1udu]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
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<StructureSection load='1udu' size='340' side='right'caption='[[1udu]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1udu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UDU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UDU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1udu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UDU FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIA:6-BENZO[1,3]DIOXOL-5-YL-2-METHYL-2,3,6,7,12,12A-HEXAHYDRO-PYRAZINO[1,2 1,6]PYRIDO[3,4-B]INDOLE-1,4-DIONE'>CIA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.83&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1udt|1udt]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIA:6-BENZO[1,3]DIOXOL-5-YL-2-METHYL-2,3,6,7,12,12A-HEXAHYDRO-PYRAZINO[1,2 1,6]PYRIDO[3,4-B]INDOLE-1,4-DIONE'>CIA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1udu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1udu OCA], [https://pdbe.org/1udu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1udu RCSB], [https://www.ebi.ac.uk/pdbsum/1udu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1udu ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1udu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1udu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1udu RCSB], [http://www.ebi.ac.uk/pdbsum/1udu PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ud/1udu_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ud/1udu_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1udu ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1udu" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Phosphodiesterase|Phosphodiesterase]]
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Cho, J M.]]
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[[Category: Large Structures]]
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[[Category: Eum, S J.]]
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[[Category: Cho JM]]
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[[Category: Heo, Y S.]]
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[[Category: Eum SJ]]
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[[Category: Hwang, K Y.]]
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[[Category: Heo Y-S]]
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[[Category: Hyun, Y L.]]
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[[Category: Hwang KY]]
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[[Category: Jeon, Y H.]]
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[[Category: Hyun Y-L]]
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[[Category: Kim, E.]]
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[[Category: Jeon YH]]
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[[Category: Kim, J H.]]
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[[Category: Kim E]]
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[[Category: Lee, J I.]]
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[[Category: Kim JH]]
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[[Category: Lee, J O.]]
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[[Category: Lee J-O]]
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[[Category: Lee, T G.]]
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[[Category: Lee JI]]
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[[Category: Moon, J.]]
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[[Category: Lee TG]]
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[[Category: Park, S Y.]]
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[[Category: Moon J]]
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[[Category: Ro, S.]]
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[[Category: Park S-Y]]
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[[Category: Sung, B J.]]
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[[Category: Ro S]]
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[[Category: Yoon, J M.]]
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[[Category: Sung B-J]]
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[[Category: Cgmp-specific phosphodiesterase 5]]
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[[Category: Yoon JM]]
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[[Category: Hydrolase]]
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[[Category: Selective inhibitor]]
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[[Category: Tadalafil]]
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Current revision

Crystal structure of Human Phosphodiesterase 5 complexed with tadalafil(Cialis)

PDB ID 1udu

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