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1ug4
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ug4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UG4 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1ug4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UG4 FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ug4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ug4 OCA], [https://pdbe.org/1ug4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ug4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ug4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ug4 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ug4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ug4 OCA], [https://pdbe.org/1ug4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ug4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ug4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ug4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/3SAN_NAJAT 3SAN_NAJAT] Basic protein that bind to cell membrane and depolarizes cardiomyocytes. This cytotoxin also shows lytic activities, on many other cells including red blood cells. Interaction with sulfatides in the cell membrane induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation. Inhibits protein kinases C (By similarity). It binds to the integrin alpha-V/beta-3 with a moderate affinity (PubMed:16407244).<ref>PMID:16407244</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Naja atra]] | [[Category: Naja atra]] | ||
| - | [[Category: Chen | + | [[Category: Chen C-J]] |
| - | [[Category: Chung | + | [[Category: Chung F-Y]] |
| - | [[Category: Wu | + | [[Category: Wu W-G]] |
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Current revision
Crystal Structure of Cardiotoxin VI from Taiwan Cobra (Naja atra) Venom
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