This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ugv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (23:53, 27 December 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1ugv.png|left|200px]]
 
-
{{STRUCTURE_1ugv| PDB=1ugv | SCENE= }}
+
==Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)==
-
 
+
<StructureSection load='1ugv' size='340' side='right'caption='[[1ugv]]' scene=''>
-
===Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1ugv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UGV FirstGlance]. <br>
-
 
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ugv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugv OCA], [https://pdbe.org/1ugv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ugv RCSB], [https://www.ebi.ac.uk/pdbsum/1ugv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ugv ProSAT], [https://www.topsan.org/Proteins/RSGI/1ugv TOPSAN]</span></td></tr>
-
[[1ugv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGV OCA].
+
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN] Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:[https://omim.org/entry/607785 607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN] GTPase-activating protein for RHOA and CDC42.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ug/1ugv_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ugv ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Aoki, M.]]
+
[[Category: Large Structures]]
-
[[Category: Hayashi, F.]]
+
[[Category: Aoki M]]
-
[[Category: Hirota, H.]]
+
[[Category: Hayashi F]]
-
[[Category: Inoue, K.]]
+
[[Category: Hirota H]]
-
[[Category: Inoue, M.]]
+
[[Category: Inoue K]]
-
[[Category: Kigawa, T.]]
+
[[Category: Inoue M]]
-
[[Category: Kikuno, R.]]
+
[[Category: Kigawa T]]
-
[[Category: Matsuda, T.]]
+
[[Category: Kikuno R]]
-
[[Category: Matsuo, Y.]]
+
[[Category: Matsuda T]]
-
[[Category: Nagase, T.]]
+
[[Category: Matsuo Y]]
-
[[Category: Nakayama, M.]]
+
[[Category: Nagase T]]
-
[[Category: Ohara, O.]]
+
[[Category: Nakayama M]]
-
[[Category: Osanai, T.]]
+
[[Category: Ohara O]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Osanai T]]
-
[[Category: Seki, E.]]
+
[[Category: Seki E]]
-
[[Category: Shirouzu, M.]]
+
[[Category: Shirouzu M]]
-
[[Category: Tanaka, A.]]
+
[[Category: Tanaka A]]
-
[[Category: Terada, T.]]
+
[[Category: Terada T]]
-
[[Category: Yabuki, T.]]
+
[[Category: Yabuki T]]
-
[[Category: Yokoyama, S.]]
+
[[Category: Yokoyama S]]
-
[[Category: Yoshida, M.]]
+
[[Category: Yoshida M]]
-
[[Category: Beta barrel]]
+
-
[[Category: Graf protein]]
+
-
[[Category: Protein binding]]
+
-
[[Category: Riken structural genomics/proteomics initiative]]
+
-
[[Category: Rsgi]]
+
-
[[Category: Structural genomic]]
+

Current revision

Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)

PDB ID 1ugv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ugv"
Personal tools