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1uhf
From Proteopedia
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| - | [[Image:1uhf.jpg|left|200px]]<br /><applet load="1uhf" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1uhf" /> | ||
| - | '''Solution Structure of the third SH3 domain of human intersectin 2(KIAA1256)'''<br /> | ||
| - | == | + | ==Solution Structure of the third SH3 domain of human intersectin 2(KIAA1256)== |
| - | + | <StructureSection load='1uhf' size='340' side='right'caption='[[1uhf]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | [[ | + | <table><tr><td colspan='2'>[[1uhf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UHF FirstGlance]. <br> |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uhf OCA], [https://pdbe.org/1uhf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uhf RCSB], [https://www.ebi.ac.uk/pdbsum/1uhf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uhf ProSAT], [https://www.topsan.org/Proteins/RSGI/1uhf TOPSAN]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/ITSN2_HUMAN ITSN2_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).<ref>PMID:19458185</ref> <ref>PMID:22648170</ref> | |
| - | [ | + | == Evolutionary Conservation == |
| - | [ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [ | + | Check<jmol> |
| - | [[ | + | <jmolCheckbox> |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uh/1uhf_consurf.spt"</scriptWhenChecked> | |
| - | [ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [[ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | [ | + | </jmolCheckbox> |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uhf ConSurf]. | |
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Intersectin|Intersectin]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hatanaka H]] | ||
| + | [[Category: Inoue M]] | ||
| + | [[Category: Kigawa T]] | ||
| + | [[Category: Koshiba S]] | ||
| + | [[Category: Shirouzu M]] | ||
| + | [[Category: Suzuki S]] | ||
| + | [[Category: Terada T]] | ||
| + | [[Category: Yokoyama S]] | ||
Current revision
Solution Structure of the third SH3 domain of human intersectin 2(KIAA1256)
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Categories: Homo sapiens | Large Structures | Hatanaka H | Inoue M | Kigawa T | Koshiba S | Shirouzu M | Suzuki S | Terada T | Yokoyama S
