1uhs

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (23:53, 27 December 2023) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1uhs.jpg|left|200px]]
 
-
{{Structure
+
==Solution structure of mouse homeodomain-only protein HOP==
-
|PDB= 1uhs |SIZE=350|CAPTION= <scene name='initialview01'>1uhs</scene>
+
<StructureSection load='1uhs' size='340' side='right'caption='[[1uhs]]' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[1uhs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UHS FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
|GENE= RIKEN cDNA 1110018K11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uhs OCA], [https://pdbe.org/1uhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uhs RCSB], [https://www.ebi.ac.uk/pdbsum/1uhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uhs ProSAT], [https://www.topsan.org/Proteins/RSGI/1uhs TOPSAN]</span></td></tr>
-
|DOMAIN=
+
</table>
-
|RELATEDENTRY=
+
== Function ==
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uhs OCA], [http://www.ebi.ac.uk/pdbsum/1uhs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1uhs RCSB]</span>
+
[https://www.uniprot.org/uniprot/HOP_MOUSE HOP_MOUSE] Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy.<ref>PMID:12297045</ref> <ref>PMID:12297046</ref>
-
}}
+
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uh/1uhs_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uhs ConSurf].
 +
<div style="clear:both"></div>
-
'''Solution structure of mouse homeodomain-only protein HOP'''
+
==See Also==
-
 
+
*[[HOP protein|HOP protein]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
1UHS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UHS OCA].
+
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Single protein]]
+
[[Category: Aoki M]]
-
[[Category: Aoki, M.]]
+
[[Category: Arakawa T]]
-
[[Category: Arakawa, T.]]
+
[[Category: Carninci P]]
-
[[Category: Carninci, P.]]
+
[[Category: Hayashizaki Y]]
-
[[Category: Hayashizaki, Y.]]
+
[[Category: Hirota H]]
-
[[Category: Hirota, H.]]
+
[[Category: Inoue M]]
-
[[Category: Inoue, M.]]
+
[[Category: Kawai J]]
-
[[Category: Kawai, J.]]
+
[[Category: Kigawa T]]
-
[[Category: Kigawa, T.]]
+
[[Category: Koshiba S]]
-
[[Category: Koshiba, S.]]
+
[[Category: Matsuda T]]
-
[[Category: Matsuda, T.]]
+
[[Category: Osanai T]]
-
[[Category: Osanai, T.]]
+
[[Category: Saito K]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Seki E]]
-
[[Category: Saito, K.]]
+
[[Category: Shirouzu M]]
-
[[Category: Seki, E.]]
+
[[Category: Tanaka A]]
-
[[Category: Shirouzu, M.]]
+
[[Category: Terada T]]
-
[[Category: Tanaka, A.]]
+
[[Category: Yabuki T]]
-
[[Category: Terada, T.]]
+
[[Category: Yokoyama S]]
-
[[Category: Yabuki, T.]]
+
[[Category: Yoshida M]]
-
[[Category: Yokoyama, S.]]
+
-
[[Category: Yoshida, M.]]
+
-
[[Category: cardiac development]]
+
-
[[Category: riken structural genomics/proteomics initiative]]
+
-
[[Category: rsgi]]
+
-
[[Category: structural genomic]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:10:28 2008''
+

Current revision

Solution structure of mouse homeodomain-only protein HOP

PDB ID 1uhs

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1uhs"
Personal tools