1uhs

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(New page: 200px<br /><applet load="1uhs" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uhs" /> '''Solution structure of mouse homeodomain-only...)
Current revision (23:53, 27 December 2023) (edit) (undo)
 
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[[Image:1uhs.jpg|left|200px]]<br /><applet load="1uhs" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1uhs" />
 
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'''Solution structure of mouse homeodomain-only protein HOP'''<br />
 
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==About this Structure==
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==Solution structure of mouse homeodomain-only protein HOP==
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1UHS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UHS OCA].
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<StructureSection load='1uhs' size='340' side='right'caption='[[1uhs]]' scene=''>
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[[Category: Mus musculus]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[1uhs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UHS FirstGlance]. <br>
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[[Category: Aoki, M.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Arakawa, T.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uhs OCA], [https://pdbe.org/1uhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uhs RCSB], [https://www.ebi.ac.uk/pdbsum/1uhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uhs ProSAT], [https://www.topsan.org/Proteins/RSGI/1uhs TOPSAN]</span></td></tr>
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[[Category: Carninci, P.]]
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</table>
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[[Category: Hayashizaki, Y.]]
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== Function ==
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[[Category: Hirota, H.]]
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[https://www.uniprot.org/uniprot/HOP_MOUSE HOP_MOUSE] Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy.<ref>PMID:12297045</ref> <ref>PMID:12297046</ref>
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[[Category: Inoue, M.]]
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== Evolutionary Conservation ==
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[[Category: Kawai, J.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Kigawa, T.]]
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Check<jmol>
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[[Category: Koshiba, S.]]
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<jmolCheckbox>
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[[Category: Matsuda, T.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uh/1uhs_consurf.spt"</scriptWhenChecked>
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[[Category: Osanai, T.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Saito, K.]]
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</jmolCheckbox>
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[[Category: Seki, E.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uhs ConSurf].
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[[Category: Shirouzu, M.]]
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<div style="clear:both"></div>
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[[Category: Tanaka, A.]]
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[[Category: Terada, T.]]
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[[Category: Yabuki, T.]]
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[[Category: Yokoyama, S.]]
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[[Category: Yoshida, M.]]
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[[Category: cardiac development]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomics]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 04:08:23 2007''
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==See Also==
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*[[HOP protein|HOP protein]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Aoki M]]
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[[Category: Arakawa T]]
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[[Category: Carninci P]]
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[[Category: Hayashizaki Y]]
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[[Category: Hirota H]]
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[[Category: Inoue M]]
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[[Category: Kawai J]]
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[[Category: Kigawa T]]
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[[Category: Koshiba S]]
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[[Category: Matsuda T]]
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[[Category: Osanai T]]
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[[Category: Saito K]]
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[[Category: Seki E]]
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[[Category: Shirouzu M]]
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[[Category: Tanaka A]]
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[[Category: Terada T]]
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[[Category: Yabuki T]]
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[[Category: Yokoyama S]]
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[[Category: Yoshida M]]

Current revision

Solution structure of mouse homeodomain-only protein HOP

PDB ID 1uhs

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