1uiz
From Proteopedia
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==Crystal Structure Of Macrophage Migration Inhibitory Factor From Xenopus Laevis.== | ==Crystal Structure Of Macrophage Migration Inhibitory Factor From Xenopus Laevis.== | ||
| - | <StructureSection load='1uiz' size='340' side='right' caption='[[1uiz]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='1uiz' size='340' side='right'caption='[[1uiz]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1uiz]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1uiz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UIZ FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | <table> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uiz OCA], [https://pdbe.org/1uiz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uiz RCSB], [https://www.ebi.ac.uk/pdbsum/1uiz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uiz ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MIF_XENLA MIF_XENLA] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense (By similarity). Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. Required for normal neural development during embryogenesis.[UniProtKB:P14174]<ref>PMID:15024012</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ui/1uiz_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ui/1uiz_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uiz ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 1uiz" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Macrophage inhibitory factor|Macrophage inhibitory factor]] | + | *[[Macrophage inhibitory factor 3D structures|Macrophage inhibitory factor 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Xenopus laevis]] | [[Category: Xenopus laevis]] | ||
| - | [[Category: Ishibashi | + | [[Category: Ishibashi T]] |
| - | [[Category: Iyaguchi | + | [[Category: Iyaguchi D]] |
| - | [[Category: Maeno | + | [[Category: Maeno M]] |
| - | [[Category: Nishihira | + | [[Category: Nishihira J]] |
| - | [[Category: Suzuki | + | [[Category: Suzuki M]] |
| - | [[Category: Takamura | + | [[Category: Takamura Y]] |
| - | [[Category: Tanaka | + | [[Category: Tanaka I]] |
| - | [[Category: Tochinai | + | [[Category: Tochinai S]] |
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Current revision
Crystal Structure Of Macrophage Migration Inhibitory Factor From Xenopus Laevis.
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Categories: Large Structures | Xenopus laevis | Ishibashi T | Iyaguchi D | Maeno M | Nishihira J | Suzuki M | Takamura Y | Tanaka I | Tochinai S
