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1um7

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{{Seed}}
 
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[[Image:1um7.png|left|200px]]
 
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==Solution structure of the third PDZ domain of synapse-associated protein 102==
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The line below this paragraph, containing "STRUCTURE_1um7", creates the "Structure Box" on the page.
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<StructureSection load='1um7' size='340' side='right'caption='[[1um7]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1um7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UM7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1um7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1um7 OCA], [https://pdbe.org/1um7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1um7 RCSB], [https://www.ebi.ac.uk/pdbsum/1um7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1um7 ProSAT], [https://www.topsan.org/Proteins/RSGI/1um7 TOPSAN]</span></td></tr>
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{{STRUCTURE_1um7| PDB=1um7 | SCENE= }}
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</table>
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== Disease ==
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===Solution structure of the third PDZ domain of synapse-associated protein 102===
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[https://www.uniprot.org/uniprot/DLG3_HUMAN DLG3_HUMAN] Defects in DLG3 are the cause of mental retardation X-linked type 90 (MRX90) [MIM:[https://omim.org/entry/300850 300850]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.<ref>PMID:15185169</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/DLG3_HUMAN DLG3_HUMAN] Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.
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==About this Structure==
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== Evolutionary Conservation ==
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1UM7 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UM7 OCA].
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/um/1um7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1um7 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hayashi, F.]]
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[[Category: Large Structures]]
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[[Category: Nagashima, T.]]
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[[Category: Hayashi F]]
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[[Category: Qin, X R.]]
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[[Category: Nagashima T]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Qin X-R]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Discs large homolog 3]]
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[[Category: Dlg3-human presynaptic protein]]
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[[Category: Pdz]]
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[[Category: Protein binding]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 08:56:34 2009''
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Current revision

Solution structure of the third PDZ domain of synapse-associated protein 102

PDB ID 1um7

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