This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1v3u

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (23:57, 27 December 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='1v3u' size='340' side='right'caption='[[1v3u]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='1v3u' size='340' side='right'caption='[[1v3u]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[1v3u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cavpo Cavpo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V3U FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[1v3u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cavia_porcellus Cavia porcellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V3U FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1v3t|1v3t]], [[1v3v|1v3v]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/15-oxoprostaglandin_13-oxidase 15-oxoprostaglandin 13-oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.48 1.3.1.48] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v3u OCA], [https://pdbe.org/1v3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v3u RCSB], [https://www.ebi.ac.uk/pdbsum/1v3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v3u ProSAT], [https://www.topsan.org/Proteins/RSGI/1v3u TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v3u OCA], [https://pdbe.org/1v3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v3u RCSB], [https://www.ebi.ac.uk/pdbsum/1v3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v3u ProSAT], [https://www.topsan.org/Proteins/RSGI/1v3u TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/PTGR1_CAVPO PTGR1_CAVPO]] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.
+
[https://www.uniprot.org/uniprot/PTGR1_CAVPO PTGR1_CAVPO] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 37: Line 36:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: 15-oxoprostaglandin 13-oxidase]]
+
[[Category: Cavia porcellus]]
-
[[Category: Cavpo]]
+
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Ago, H]]
+
[[Category: Ago H]]
-
[[Category: Hori, T]]
+
[[Category: Hori T]]
-
[[Category: Kumasaka, T]]
+
[[Category: Kumasaka T]]
-
[[Category: Miyano, M]]
+
[[Category: Miyano M]]
-
[[Category: Structural genomic]]
+
[[Category: Shimizu T]]
-
[[Category: Shimizu, T]]
+
[[Category: Sugahara M]]
-
[[Category: Sugahara, M]]
+
[[Category: Ueno G]]
-
[[Category: Ueno, G]]
+
[[Category: Yamamoto M]]
-
[[Category: Yamamoto, M]]
+
[[Category: Yokomizo T]]
-
[[Category: Yokomizo, T]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Rossmann fold]]
+
-
[[Category: Rsgi]]
+

Current revision

Crystal structure of leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase in apo form

PDB ID 1v3u

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1v3u"
Personal tools