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1v5m
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==Solution Structure of the Pleckstrin Homology Domain of Mouse APS== | ==Solution Structure of the Pleckstrin Homology Domain of Mouse APS== | ||
| - | <StructureSection load='1v5m' size='340' side='right'caption='[[1v5m | + | <StructureSection load='1v5m' size='340' side='right'caption='[[1v5m]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1v5m]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1v5m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V5M FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v5m OCA], [https://pdbe.org/1v5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v5m RCSB], [https://www.ebi.ac.uk/pdbsum/1v5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v5m ProSAT], [https://www.topsan.org/Proteins/RSGI/1v5m TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/SH2B2_MOUSE SH2B2_MOUSE] Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3 (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: Inoue | + | [[Category: Inoue M]] |
| - | [[Category: Kigawa | + | [[Category: Kigawa T]] |
| - | [[Category: Koshiba | + | [[Category: Koshiba S]] |
| - | [[Category: Li | + | [[Category: Li H]] |
| - | + | [[Category: Tochio N]] | |
| - | [[Category: Tochio | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
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Current revision
Solution Structure of the Pleckstrin Homology Domain of Mouse APS
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Categories: Large Structures | Mus musculus | Inoue M | Kigawa T | Koshiba S | Li H | Tochio N | Yokoyama S
