1v5r
From Proteopedia
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==Solution Structure of the Gas2 Domain of the Growth Arrest Specific 2 Protein== | ==Solution Structure of the Gas2 Domain of the Growth Arrest Specific 2 Protein== | ||
| - | <StructureSection load='1v5r' size='340' side='right'caption='[[1v5r | + | <StructureSection load='1v5r' size='340' side='right'caption='[[1v5r]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1v5r]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1v5r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V5R FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v5r OCA], [https://pdbe.org/1v5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v5r RCSB], [https://www.ebi.ac.uk/pdbsum/1v5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v5r ProSAT], [https://www.topsan.org/Proteins/RSGI/1v5r TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/GAS2_MOUSE GAS2_MOUSE] May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May play a role in chondrocyte proliferation and differentiation, and in limb myogenesis. May be involved in the regulation of the apoptosis in the interdigital tissues of the developing hindlimb. May be involved in the membrane ruffling process.<ref>PMID:10049561</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: Inoue | + | [[Category: Inoue M]] |
| - | [[Category: Kigawa | + | [[Category: Kigawa T]] |
| - | [[Category: Koshiba | + | [[Category: Koshiba S]] |
| - | [[Category: Miyamoto | + | [[Category: Miyamoto K]] |
| - | + | [[Category: Yokoyama S]] | |
| - | [[Category: Yokoyama | + | |
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Current revision
Solution Structure of the Gas2 Domain of the Growth Arrest Specific 2 Protein
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