1v87

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1v87" size="450" color="white" frame="true" align="right" spinBox="true" caption="1v87" /> '''Solution Structure of the Ring-H2 Finger Dom...)
Current revision (23:59, 27 December 2023) (edit) (undo)
 
(15 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1v87.gif|left|200px]]<br /><applet load="1v87" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1v87" />
 
-
'''Solution Structure of the Ring-H2 Finger Domain of Mouse Deltex Protein 2'''<br />
 
-
==About this Structure==
+
==Solution Structure of the Ring-H2 Finger Domain of Mouse Deltex Protein 2==
-
1V87 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1V87 OCA].
+
<StructureSection load='1v87' size='340' side='right'caption='[[1v87]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1v87]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V87 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V87 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v87 OCA], [https://pdbe.org/1v87 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v87 RCSB], [https://www.ebi.ac.uk/pdbsum/1v87 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v87 ProSAT], [https://www.topsan.org/Proteins/RSGI/1v87 TOPSAN]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/DTX2_MOUSE DTX2_MOUSE] Recurrent site of retroviral integration in murine B-cell lymphomas.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/DTX2_MOUSE DTX2_MOUSE] Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v8/1v87_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v87 ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Single protein]]
+
[[Category: Inoue M]]
-
[[Category: Inoue, M.]]
+
[[Category: Kigawa T]]
-
[[Category: Kigawa, T.]]
+
[[Category: Koshiba S]]
-
[[Category: Koshiba, S.]]
+
[[Category: Miyamoto K]]
-
[[Category: Miyamoto, K.]]
+
[[Category: Muto Y]]
-
[[Category: Muto, Y.]]
+
[[Category: Tochio N]]
-
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
+
[[Category: Yokoyama S]]
-
[[Category: Tochio, N.]]
+
-
[[Category: Yokoyama, S.]]
+
-
[[Category: ZN]]
+
-
[[Category: notch signaling]]
+
-
[[Category: riken structural genomics/proteomics initiative]]
+
-
[[Category: ring-h2 domain]]
+
-
[[Category: rsgi]]
+
-
[[Category: structural genomics]]
+
-
[[Category: zinc-binding domain]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 04:30:17 2007''
+

Current revision

Solution Structure of the Ring-H2 Finger Domain of Mouse Deltex Protein 2

PDB ID 1v87

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1v87"
Personal tools