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2irf
From Proteopedia
(Difference between revisions)
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<StructureSection load='2irf' size='340' side='right'caption='[[2irf]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='2irf' size='340' side='right'caption='[[2irf]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2irf]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2irf]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IRF FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5IU:5-IODO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>5IU</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2irf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2irf OCA], [https://pdbe.org/2irf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2irf RCSB], [https://www.ebi.ac.uk/pdbsum/2irf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2irf ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2irf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2irf OCA], [https://pdbe.org/2irf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2irf RCSB], [https://www.ebi.ac.uk/pdbsum/2irf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2irf ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/IRF2_MOUSE IRF2_MOUSE] Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: Fujii | + | [[Category: Fujii Y]] |
| - | [[Category: Hakoshima | + | [[Category: Hakoshima T]] |
| - | [[Category: Kusumoto | + | [[Category: Kusumoto M]] |
| - | [[Category: Kyogoku | + | [[Category: Kyogoku Y]] |
| - | [[Category: Shimizu | + | [[Category: Shimizu T]] |
| - | [[Category: Taniguchi | + | [[Category: Taniguchi T]] |
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Current revision
CRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX.
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