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2nla

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{{Seed}}
 
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[[Image:2nla.png|left|200px]]
 
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==Crystal structure of the Mcl-1:mNoxaB BH3 complex==
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The line below this paragraph, containing "STRUCTURE_2nla", creates the "Structure Box" on the page.
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<StructureSection load='2nla' size='340' side='right'caption='[[2nla]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2nla]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NLA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nla OCA], [https://pdbe.org/2nla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nla RCSB], [https://www.ebi.ac.uk/pdbsum/2nla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nla ProSAT]</span></td></tr>
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{{STRUCTURE_2nla| PDB=2nla | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nl/2nla_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nla ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Apoptosis is held in check by prosurvival proteins of the Bcl-2 family. The distantly related BH3-only proteins bind to and antagonize them, thereby promoting apoptosis. Whereas binding of the BH3-only protein Noxa to prosurvival Mcl-1 induces Mcl-1 degradation by the proteasome, binding of another BH3-only ligand, Bim, elevates Mcl-1 protein levels. We compared the three-dimensional structures of the complexes formed between BH3 peptides of both Bim and Noxa, and we show that a discrete C-terminal sequence of the Noxa BH3 is necessary to instigate Mcl-1 degradation.
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===Crystal structure of the Mcl-1:mNoxaB BH3 complex===
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Structural insights into the degradation of Mcl-1 induced by BH3 domains.,Czabotar PE, Lee EF, van Delft MF, Day CL, Smith BJ, Huang DC, Fairlie WD, Hinds MG, Colman PM Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6217-22. Epub 2007 Mar 27. PMID:17389404<ref>PMID:17389404</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2nla" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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2NLA is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus_and_homo_sapiens Rattus norvegicus and homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLA OCA].
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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[[Category: Rattus norvegicus and homo sapiens]]
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== References ==
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[[Category: Colman, P M.]]
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<references/>
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[[Category: Czabotar, P E.]]
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__TOC__
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[[Category: Apoptosis]]
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</StructureSection>
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[[Category: Bcl-2]]
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[[Category: Homo sapiens]]
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[[Category: Mcl-1]]
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[[Category: Large Structures]]
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[[Category: Noxa]]
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[[Category: Mus musculus]]
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[[Category: Colman PM]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 03:53:53 2009''
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[[Category: Czabotar PE]]

Current revision

Crystal structure of the Mcl-1:mNoxaB BH3 complex

PDB ID 2nla

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