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2npl

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(New page: 200px<br /> <applet load="2npl" size="450" color="white" frame="true" align="right" spinBox="true" caption="2npl" /> '''NMR Structure of CARD d2 Domain'''<br /> =...)
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[[Image:2npl.gif|left|200px]]<br />
 
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<applet load="2npl" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2npl" />
 
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'''NMR Structure of CARD d2 Domain'''<br />
 
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==Overview==
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==NMR Structure of CARD d2 Domain==
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The coxsackievirus and adenovirus receptor (CAR) mediates entry of, coxsackievirus and adenovirus. CAR possesses an extracellular region that, is comprised of 2 immunoglobulin domains termed CAR-D1 and CAR-D2. In the, present work, the solution structure of CAR-D2, consisting of residues, 142-235 of human CAR, has been determined by NMR spectroscopy. CAR-D2 is, shown to be a beta-sandwich motif comprised of two beta-sheets, which are, stabilized by two disulfide bonds. The first beta-sheet is comprised of, beta-strands A, B, and E, and the second beta-sheet is comprised of, beta-strands C, F, and G. A relatively hydrophobic helix is found between, beta-strands C and E, which replaces beta-strand D of the classical c-type, immunoglobulin fold.
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<StructureSection load='2npl' size='340' side='right'caption='[[2npl]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2npl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NPL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2npl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2npl OCA], [https://pdbe.org/2npl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2npl RCSB], [https://www.ebi.ac.uk/pdbsum/2npl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2npl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CXAR_HUMAN CXAR_HUMAN] Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN.<ref>PMID:9096397</ref> <ref>PMID:11734628</ref> <ref>PMID:12297051</ref> <ref>PMID:15800062</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/np/2npl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2npl ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The coxsackievirus and adenovirus receptor (CAR) mediates entry of coxsackievirus and adenovirus. CAR possesses an extracellular region that is comprised of 2 immunoglobulin domains termed CAR-D1 and CAR-D2. In the present work, the solution structure of CAR-D2, consisting of residues 142-235 of human CAR, has been determined by NMR spectroscopy. CAR-D2 is shown to be a beta-sandwich motif comprised of two beta-sheets, which are stabilized by two disulfide bonds. The first beta-sheet is comprised of beta-strands A, B, and E, and the second beta-sheet is comprised of beta-strands C, F, and G. A relatively hydrophobic helix is found between beta-strands C and E, which replaces beta-strand D of the classical c-type immunoglobulin fold.
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==Disease==
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Solution structure of the coxsackievirus and adenovirus receptor domain 2.,Jiang S, Caffrey M Protein Sci. 2007 Mar;16(3):539-42. PMID:17322536<ref>PMID:17322536</ref>
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Known diseases associated with this structure: Adrenocortical tumor, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188830 188830]], Carney complex, type 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188830 188830]], Myxoma, intracardiac OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188830 188830]], Pigmented adrenocortical disease, primary, 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188830 188830]], Spastic paraplegia-7 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602783 602783]], Thyroid carcinoma, papillary OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188830 188830]]
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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2NPL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2NPL OCA].
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</div>
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<div class="pdbe-citations 2npl" style="background-color:#fffaf0;"></div>
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==Reference==
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== References ==
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Solution structure of the coxsackievirus and adenovirus receptor domain 2., Jiang S, Caffrey M, Protein Sci. 2007 Mar;16(3):539-42. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17322536 17322536]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Caffrey, M.]]
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[[Category: Caffrey M]]
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[[Category: Jiang, S.]]
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[[Category: Jiang S]]
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[[Category: coxsakievirus and adenovirus receptor]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:01:24 2007''
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Current revision

NMR Structure of CARD d2 Domain

PDB ID 2npl

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