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2o03

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==Crystal structure of FurB from M. tuberculosis- a Zinc uptake regulator==
==Crystal structure of FurB from M. tuberculosis- a Zinc uptake regulator==
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<StructureSection load='2o03' size='340' side='right' caption='[[2o03]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='2o03' size='340' side='right'caption='[[2o03]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2o03]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O03 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O03 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2o03]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O03 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.699&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">furB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o03 OCA], [http://pdbe.org/2o03 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2o03 RCSB], [http://www.ebi.ac.uk/pdbsum/2o03 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2o03 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o03 OCA], [https://pdbe.org/2o03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o03 RCSB], [https://www.ebi.ac.uk/pdbsum/2o03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o03 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ZUR_MYCTU ZUR_MYCTU]] Global transcriptional regulator involved in zinc homeostasis. Represses the transcription of at least 32 genes, including genes involved in zinc homeostasis, by binding to promoter sequences that contain a conserved 26 bp palindrome, in the presence of zinc.<ref>PMID:17098899</ref>
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[https://www.uniprot.org/uniprot/ZUR_MYCTU ZUR_MYCTU] Global transcriptional regulator involved in zinc homeostasis. Represses the transcription of at least 32 genes, including genes involved in zinc homeostasis, by binding to promoter sequences that contain a conserved 26 bp palindrome, in the presence of zinc.<ref>PMID:17098899</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o0/2o03_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o0/2o03_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lucarelli, D]]
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[[Category: Large Structures]]
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[[Category: Pohl, E]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Russo, S]]
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[[Category: Lucarelli D]]
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[[Category: Dna-binding]]
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[[Category: Pohl E]]
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[[Category: Gene regulation]]
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[[Category: Russo S]]
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[[Category: Helix-turn-helix]]
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[[Category: Zinc binding]]
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[[Category: Zinc uptake]]
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Current revision

Crystal structure of FurB from M. tuberculosis- a Zinc uptake regulator

PDB ID 2o03

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